The Administrative Core of the Center for Skeletal Research will have responsibility for managing the Core Facilities, the Pilot Project Program, and the Enrichment Program ofthe Center. Ms. Lynn Moulton, as Administrator, and Ms. Latanya Turner, as fiscal Officer, will assist Dr. Henry Kronenberg ((Program Director) and Dr. Marie Demay (Associate Program Director). An advisory Committee, which will include 3 members from outside institutions, will meet with this group regularly to provide advice about all aspects of management. This committee will meet four times a year with the Core Directors Committee that will meet monthly. A major principle of management will be that the Core Facilities must serve as engines of technological innovation; the anticipated changing menu of core offerings will require ongoing evaluation by the Core Directors and Advisory Committees. Another major principle is that the Core budgets will depend on user fees to cover most supply costs associated with Core services. This principle will allow the funding of several technicians who will provide services not othenwise easily obtained by Center investigators. Dr. Marie Demay will head a committee charged with the management of the Pilot and Feasibility Program. Ms. Moulton and Ms. Maclaughlin will manage the content of a Center website that will be used to coordinate and advertise Center activities and will also be interactive to allow fiscal management of all Research Cores and to allow the Cores to identify and track samples and Center investigators to communicate with each other. A seminar series will be planned to expand upon a currently existing series in a way that will expand the scope of the series and provide another setting for teaching by Core staff and feedback to the Cores from the research base. Ongoing evaluation of all programs through the polling of the research base and continually finding ways to foster collaborations will be major goals of Center leadership.

Public Health Relevance

Core facilities that develop novel technologies to drive the science of a talented group of investigators will enrich the scientific potential of the investigators and further collabortion. A program to provide funds for pilot projects will focus on bringing young investigators into the field. All of these efforts will lead to novel strategies to diagnose and treat bone diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR066261-02
Application #
8853822
Study Section
Special Emphasis Panel (ZAR1-XZ)
Project Start
Project End
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
2
Fiscal Year
2015
Total Cost
$177,308
Indirect Cost
$75,407
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Noguchi, Takashi; Hussein, Amira I; Horowitz, Nina et al. (2018) Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm. Sci Rep 8:13756
Christov, Marta; Clark, Abbe R; Corbin, Braden et al. (2018) Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight 3:
Dedic, Christopher; Hung, Tin Shing; Shipley, Alan M et al. (2018) Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes. Bone 116:135-143
Karaca, Anara; Malladi, Vijayram Reddy; Zhu, Yan et al. (2018) Constitutive stimulatory G protein activity in limb mesenchyme impairs bone growth. Bone 110:230-237
Kiapour, Ata M; Cao, Jiaxue; Young, Mariel et al. (2018) The role of Gdf5 regulatory regions in development of hip morphology. PLoS One 13:e0202785
Farrell, Mariah L; Reagan, Michaela R (2018) Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma. Front Endocrinol (Lausanne) 9:218
Cox, Kimberly H; Oliveira, Luciana M B; Plummer, Lacey et al. (2018) Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet 27:338-350
Vandoorne, Katrien; Rohde, David; Kim, Hye-Yeong et al. (2018) Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res 123:415-427
Herisson, Fanny; Frodermann, Vanessa; Courties, Gabriel et al. (2018) Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci 21:1209-1217
Wein, Marc N; Foretz, Marc; Fisher, David E et al. (2018) Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab 29:723-735

Showing the most recent 10 out of 53 publications