The Tumor Imaging Metrics Core was approved as a developing core in the last CCSG submission. The Tumor Imaging Metrics Core (TIMC) provides objective assessment of response to treatment for patients enrolled in oncology clinical trials. All major radiological assessment criteria are supported including: RECIST (1.0 and 1.1), WHO, IWRC, Cheson, SUV, Choi, 3D Volume and irRC. For each patient, target and nontarget lesions are selected according to the assessment criteria guidelines and are tracked longitudinally. Scans to be measured are transferred from DF/HCC sites to the central Core lab via DICOM imaging network. Quantitative analysis of CT, MR and PET imaging studies are performed on a variety of modalityspecific workstations. After scans are analyzed, the measurement results are reviewed and finalized by Harvard faculty radiologists and/or nuclear medicine physicians. Measurement results are stored in the TIMC database on a secure website and are viewable online by authorized trial staff. The quantitative measurements are used to determine tumor response to treatment and ultimately guide patient care. Summary statistics for the trial are presented as well as individual patient measurements. Requests for scan analysis can be conveniently ordered on-line by the trial staff. Users are authenticated via their home institution's username and password (single sign-on). Rates for sen/ices are very reasonable compared to other options available from outside DF/HCC. Director(s): Gordon J. Harris, PhD""""""""^""""""""and Annick D. Van den Abbeele, MD Category: 4.03 (Clinical - Radiology and Tumor Imaging) Management: Joint (Cancer Center and Institutional).

Public Health Relevance

The Tumor Imaging Metrics Core (TIMC) provides tumor measurements of radiological scans for oncology clinical trials. Its mission is to provide standardized measurements of CT, MR and PET imaging studies according to protocol for oncology clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA006516-49
Application #
8601473
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
49
Fiscal Year
2014
Total Cost
$254,271
Indirect Cost
$60,777
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
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