Abstract

The Monoclonal Anfibody Core provides expert consultafion on antibody development to invesfigators and supports all aspects of anfibody development, including generation of antigens, immunizations, hybridoma fusions, antibody screening, long-term hybridoma storage and small and large-scale anfibody producfion, as well as purificafion and labeling of anfibodies. The Core provides quality antibody reagents and technologies at a reasonable fee so that DF/HCC members can further their research objectives and facilitate their goal to invesfigate, diagnose and treat cancer. This facility was first approved as an Established Shared Resource at the fime ofthe last competitive renewal.

Public Health Relevance

The mission of the Core is to generate novel monoclonal and polyclonal antibodies specific for antigens of interest to Cancer Center investigators. Given the diverse research needs of DF/HCC members, the Core strives to respond to a wide variety of requests for antibody development. Antibodies can be developed for basic and translational research, including the detection of biomarkers indicative of disease status, as well as functional antibodies for therapeutic purposes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
4P30CA006516-51
Application #
8975641
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
2017-11-30
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
51
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Chen, Jingjing; Guccini, Ilaria; Di Mitri, Diletta et al. (2018) Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet 50:219-228
Li, Andrew G; Murphy, Elizabeth C; Culhane, Aedin C et al. (2018) BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1? activation. Proc Natl Acad Sci U S A 115:E9600-E9609
McBrayer, Samuel K; Mayers, Jared R; DiNatale, Gabriel J et al. (2018) Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell 175:101-116.e25
Stopsack, Konrad H; Gonzalez-Feliciano, Amparo G; Peisch, Samuel F et al. (2018) A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status. Cancer Epidemiol Biomarkers Prev 27:1231-1233
Kamareddine, Layla; Wong, Adam C N; Vanhove, Audrey S et al. (2018) Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host. Nat Microbiol 3:243-252
Schilit, Samantha L P; Morton, Cynthia C (2018) 3C-PCR: a novel proximity ligation-based approach to phase chromosomal rearrangement breakpoints with distal allelic variants. Hum Genet 137:55-62
Sievers, Quinlan L; Gasser, Jessica A; Cowley, Glenn S et al. (2018) Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. Blood 132:1293-1303
Kelley, Katherine A; Wieghard, Nicole; Chin, Yuki et al. (2018) MiR-486-5p Downregulation Marks an Early Event in Colorectal Carcinogenesis. Dis Colon Rectum 61:1290-1296
Yao, Lina; Seaton, Sarah Craven; Ndousse-Fetter, Sula et al. (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 7:
Jalbut, Marla M; Brunner, Andrew M; Amrein, Philip C et al. (2018) Early infectious complications among patients treated with induction compared to hypomethylating therapy for acute myeloid leukemia. Leuk Lymphoma 59:988-991

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