Dana-Farber/Harvard Cancer Center has a proven track record of success in designing, conducting and completing high-impact early phase clinical trials (Pilot, Phase I, Phase I/II). The development and conduct of such trials, which have the potential to transform the care of cancer patients, are challenged by the availability of funds rather than the lack of patients or novel concepts, particularly concepts arising from DF/HCC laboratories. Early Phase Clinical Research Support (EPCRS) funds are used to support research nursing and clinical research coordinator time for approved early phase trials as well as costs associated with the generation of preliminary data through other early phase clinically related activities. Preliminary data may come from pharmacodynamic studies (e.g. measurements of immune perturbation, repeat tumor biopsies, target protein levels, circulating tumor cells or DNA) for important unfunded or under-funded Early Phase trials, with a focus on facilitating the translation of new treatment or biomarker concepts from the laboratory to clinic. By supporting collaborations between laboratory and clinical investigators, EPCRS decreases time from discovery to clinical testing of new agents and approaches thus enabling the conduct of trials that might otherwise either not be conducted or else delayed.
| Agoston, Agoston T; Pham, Thai H; Odze, Robert D et al. (2018) Columnar-Lined Esophagus Develops via Wound Repair in a Surgical Model of Reflux Esophagitis. Cell Mol Gastroenterol Hepatol 6:389-404 |
| Barber, Lauren; Gerke, Travis; Markt, Sarah C et al. (2018) Family History of Breast or Prostate Cancer and Prostate Cancer Risk. Clin Cancer Res 24:5910-5917 |
| Kwee, Brian J; Budina, Erica; Najibi, Alexander J et al. (2018) CD4 T-cells regulate angiogenesis and myogenesis. Biomaterials 178:109-121 |
| Madsen, Thomas; Braun, Danielle; Peng, Gang et al. (2018) Efficient computation of the joint probability of multiple inherited risk alleles from pedigree data. Genet Epidemiol 42:528-538 |
| Chen, Jingjing; Guccini, Ilaria; Di Mitri, Diletta et al. (2018) Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet 50:219-228 |
| Li, Andrew G; Murphy, Elizabeth C; Culhane, Aedin C et al. (2018) BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1? activation. Proc Natl Acad Sci U S A 115:E9600-E9609 |
| McBrayer, Samuel K; Mayers, Jared R; DiNatale, Gabriel J et al. (2018) Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell 175:101-116.e25 |
| Stopsack, Konrad H; Gonzalez-Feliciano, Amparo G; Peisch, Samuel F et al. (2018) A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status. Cancer Epidemiol Biomarkers Prev 27:1231-1233 |
| Kamareddine, Layla; Wong, Adam C N; Vanhove, Audrey S et al. (2018) Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host. Nat Microbiol 3:243-252 |
| Schilit, Samantha L P; Morton, Cynthia C (2018) 3C-PCR: a novel proximity ligation-based approach to phase chromosomal rearrangement breakpoints with distal allelic variants. Hum Genet 137:55-62 |
Showing the most recent 10 out of 411 publications
