The mission of the Leukemia Program is to conduct innovative translational research in order to improve the therapy of leukemia and related disorders, with a focus on discoveries that will lead to improvements in diagnosis, prognosis, and therapy. The Program seeks to understand the genetics and pathogenesis of leukemia and to devise novel targeted therapies for acute leukemias, myelodysplastic syndromes, and myeloproliferative neoplasms. The program has three Specific Aims: 1) Identify novel cellular and molecular mechanisms that contribute to the pathogenesis of leukemia and related diseases; 2) Generate accurate animal models of leukemia to improve the understanding of pathogenesis and to develop targeted anti- leukemic agents; and 3) Design and implement clinical trials to translate laboratory research discoveries made within the Program and DF/HCC as a whole. The program has 73 members, representing six DF/HCC institutions and 8 academic departments. In 2014 peer-reviewed grant funding attributed to the Program was $9.8 million in total costs from the NCI and $13.6 million from other sponsors. During the current funding period, Leukemia Program members published 1,304 cancer-relevant papers. Of these 32% were inter- institutional, 26% were intra-programmatic, and 40% were inter-programmatic collaborations between two or more DF/HCC members. Overall, when counted once, 27% of DF/HCC publications were inter-programmatic collaborations.
| Kwee, Brian J; Budina, Erica; Najibi, Alexander J et al. (2018) CD4 T-cells regulate angiogenesis and myogenesis. Biomaterials 178:109-121 |
| Madsen, Thomas; Braun, Danielle; Peng, Gang et al. (2018) Efficient computation of the joint probability of multiple inherited risk alleles from pedigree data. Genet Epidemiol 42:528-538 |
| Chen, Jingjing; Guccini, Ilaria; Di Mitri, Diletta et al. (2018) Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet 50:219-228 |
| Li, Andrew G; Murphy, Elizabeth C; Culhane, Aedin C et al. (2018) BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1? activation. Proc Natl Acad Sci U S A 115:E9600-E9609 |
| McBrayer, Samuel K; Mayers, Jared R; DiNatale, Gabriel J et al. (2018) Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell 175:101-116.e25 |
| Stopsack, Konrad H; Gonzalez-Feliciano, Amparo G; Peisch, Samuel F et al. (2018) A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status. Cancer Epidemiol Biomarkers Prev 27:1231-1233 |
| Kamareddine, Layla; Wong, Adam C N; Vanhove, Audrey S et al. (2018) Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host. Nat Microbiol 3:243-252 |
| Schilit, Samantha L P; Morton, Cynthia C (2018) 3C-PCR: a novel proximity ligation-based approach to phase chromosomal rearrangement breakpoints with distal allelic variants. Hum Genet 137:55-62 |
| Sievers, Quinlan L; Gasser, Jessica A; Cowley, Glenn S et al. (2018) Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. Blood 132:1293-1303 |
| Kelley, Katherine A; Wieghard, Nicole; Chin, Yuki et al. (2018) MiR-486-5p Downregulation Marks an Early Event in Colorectal Carcinogenesis. Dis Colon Rectum 61:1290-1296 |
Showing the most recent 10 out of 411 publications
