? CANCER BIOLOGY PROGRAM The Cancer Biology (CB) Program, led by Chernoff and Testa is comprised of 19 Primary Members and 11 Collaborating Members. Program funding is $4.2M (project direct costs) annually, including $3.5M in peer- reviewed funding of which $1.9M is from the NCI. CB members have been highly productive and interactive during the past funding cycle, generating 534 publications, with 26% representing intra-programmatic and 33% representing inter-programmatic collaborations. The primary mission of the Cancer Biology (CB) Program is to determine how a normal cell becomes transformed and develops into a cancer. The Program now includes a range of studies that use cell-based and animal models, as well as patient-derived materials, to analyze and exploit altered signal transduction pathways in cancer cells, to explore interactions between tumor cells and their microenvironment, and to identify therapeutically useful properties of normal and transformed stem cells. These changes in scientific scope have been accompanied both by expansion in membership and inter- and intra-programmatic collaborations. The scientific platform of the CB Program is built on three pillars: altered cancer cell signaling, cancer stem cell biology, and the contributions of the stroma to cancer, with an overarching interest in how abnormalities in these domains promote the initiation and maintenance of cell transformation, invasion, and metastasis. The CB Program occupies a vital niche at Fox Chase Cancer Center (FCCC), allied to, but distinct from, the Molecular Therapeutics (MT) Program, and represents the core of molecular oncology research at this Institution. In addition, as the major home for signal transduction research at FCCC, the investigators in the CB Program are heavily involved in translational efforts to find useful new drug targets that regulate key neoplastic signaling pathways. Future plans center on strengthening, by means of strategic recruiting, the links between investigators studying aberrant signaling pathways in cancer cells (including cancer stem cells), and in the surrounding stroma, with the ultimate goal of translating these insights, in coordination with the MT Program, into clinical practice. All these activities are enabled by and heavily reliant upon Shared Resources as indicated by program usage of all 12 CCSG-supported Shared Resources.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA006927-54
Application #
9754613
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
54
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Research Institute of Fox Chase Cancer Center
Department
Type
DUNS #
064367329
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
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Nacson, Joseph; Krais, John J; Bernhardy, Andrea J et al. (2018) BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Rep 24:3513-3527.e7
Fahl, Shawn P; Coffey, Francis; Kain, Lisa et al. (2018) Role of a selecting ligand in shaping the murine ??-TCR repertoire. Proc Natl Acad Sci U S A 115:1889-1894
Jones, Caitlin E; Hammer, Anisha M; Cho, YouJin et al. (2018) Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland. Neoplasia 21:132-145
Shaikh, Talha; Wang, Lora S; Egleston, Brian et al. (2018) Predictors of Hematologic Toxicity and Chemotherapy Dose Intensity in Patients Undergoing Chemoradiation for Pancreatic Cancer. Am J Clin Oncol 41:59-64
Campbell, Kerry S; Cohen, Adam D; Pazina, Tatiana (2018) Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma. Front Immunol 9:2551
Blackman, Elizabeth; Ashing, Kimlin; Gibbs, Denise et al. (2018) The Cancer Prevention Project of Philadelphia: preliminary findings examining diversity among the African diaspora. Ethn Health :1-17
Fatkhullina, Aliia R; Peshkova, Iuliia O; Dzutsev, Amiran et al. (2018) An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis. Immunity 49:943-957.e9
Gupta, Sapna; Kelow, Simon; Wang, Liqun et al. (2018) Mouse modeling and structural analysis of the p.G307S mutation in human cystathionine ?-synthase (CBS) reveal effects on CBS activity but not stability. J Biol Chem 293:13921-13931
Sementino, Eleonora; Menges, Craig W; Kadariya, Yuwaraj et al. (2018) Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas. J Cell Physiol 233:8952-8961

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