Abstract

Many translational cancer research studies are based on the study of human cancer tissues. This research requires access to samples of human cancers and corresponding normal tissues and also requires expertise of qualified pathologists to assist in the appropriate use of tissues and interpretation of results. The purpose of this core is to provide a centralized resource for collecting and processing samples of solid tumors and hematologic malignancies based on the needs of Cancer Center investigators. The procurement of solid tumor tissues by the Core frequently involves selection of appropriate paraffin tissue blocks as well as collection of fresh-frozen tissue samples. The Core also provides a centralized laboratory resource for conducting immunohistochemistry, and in response to increased requests for immunochemistry on breast cancer samples, is developing breast cancer tissue arrays. Finally, the Core provides consultative services for the assessment of tissue samples and the development and interpretation of immunohistochemistry assays.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA006973-39
Application #
6481450
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
1978-01-01
Project End
2006-04-30
Budget Start
Budget End
Support Year
39
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Hyman, David M; Rizvi, Naiyer; Natale, Ronald et al. (2018) Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors. Clin Cancer Res 24:2749-2757
Guo, Hong; Barberi, Theresa; Suresh, Rahul et al. (2018) Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBP?. J Immunol 201:1692-1704
Tosoian, Jeffrey J; Guedes, Liana B; Morais, Carlos L et al. (2018) PTEN status assessment in the Johns Hopkins active surveillance cohort. Prostate Cancer Prostatic Dis :
Tran, Phuong T; Meeker, Alan K; Platz, Elizabeth A (2018) Association between statin drug use and peripheral blood leukocyte telomere length in the National Health and Nutrition Examination Survey 1999-2002: a cross-sectional study. Ann Epidemiol 28:529-534
Pallavajjala, Aparna; Kim, Daehwan; Li, Tongbin et al. (2018) Genomic characterization of chromosome translocations in patients with T/myeloid mixed-phenotype acute leukemia. Leuk Lymphoma 59:1231-1238
Dean, Lorraine T; Moss, Shadiya L; Ransome, Yusuf et al. (2018) ""It still affects our economic situation"": long-term economic burden of breast cancer and lymphedema. Support Care Cancer :
Song, Mingyang; Vogelstein, Bert; Giovannucci, Edward L et al. (2018) Cancer prevention: Molecular and epidemiologic consensus. Science 361:1317-1318
Weber, Kari A; Heaphy, Christopher M; Joshu, Corinne E et al. (2018) Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations. Cancer Causes Control 29:759-767
Haffner, Michael C; Taheri, Diana; Luidy-Imada, Eddie et al. (2018) Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors. Proc Natl Acad Sci U S A 115:E8580-E8582
Nauman, Gina; Gray, Javaughn Corey; Parkinson, Rose et al. (2018) Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials. Antioxidants (Basel) 7:

Showing the most recent 10 out of 2393 publications