The Clinical Research Review Committee (CRC) of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins is responsible for reviewing the scientific merit, priorities, and progress of the clinical protocol research of the center. Committee approval is required prior to opening a protocol in the Cancer Center. The committee also has the authority to close protocols that do not demonstrate adequate scientific progress. Over the past five years, the average number of protocols reviewed per year for scientific merit was 115 protocols. These numbers fluctuate year to year with the lowest being in 2001 (92 protocols) due to the Office of Human Research Protection (CHRP) shutdown. In 2004, 135 studies were reviewed for scientific merit. On average, in 2004 each week the committee reviewed 3 new, never-reviewed studies, 1 resubmitted study with CRC recommended changes, and 1 study for annual progress and performance. In 2004, a new CRC Prereview Committee (preCRC) was formed. The purpose of the CRC Prereview Committee is to facilitate the protocol approval process by providing investigators with early feedback on the quality and completeness of their protocols prior to CRC. In addition, the preCRC focuses on ensuring resources are available to support the trial (e.g., nursing, pharmacy, Specimen Accessioning Core). Having the new committee better allows the CRC to focus on the scientific merit, scientific priorities and progress of the research in the Center. Implementation of the preCRC has made the CRC review more efficient and improves research staff efficiency and data quality when the study opens.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA006973-45
Application #
7726503
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
45
Fiscal Year
2007
Total Cost
$48,571
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Bastos, Diogo A; Antonarakis, Emmanuel S (2018) AR-V7 and treatment selection in advanced prostate cancer: are we there yet? Precis Cancer Med 1:
Stein-O'Brien, Genevieve; Kagohara, Luciane T; Li, Sijia et al. (2018) Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance. Genome Med 10:37
Dean, Lorraine T; Montgomery, Madeline C; Raifman, Julia et al. (2018) The Affordability of Providing Sexually Transmitted Disease Services at a Safety-net Clinic. Am J Prev Med 54:552-558
Mondul, Alison M; Joshu, Corinne E; Barber, John R et al. (2018) Longer-term Lipid-lowering Drug Use and Risk of Incident and Fatal Prostate Cancer in Black and White Men in the ARIC Study. Cancer Prev Res (Phila) 11:779-788
Lu, Dai-Yin; Yalçin, Hulya; Yalçin, Fatih et al. (2018) Stress Myocardial Blood Flow Heterogeneity Is a Positron Emission Tomography Biomarker of Ventricular Arrhythmias in Patients With Hypertrophic Cardiomyopathy. Am J Cardiol 121:1081-1089
Brundage, Michael; Blackford, Amanda; Tolbert, Elliott et al. (2018) Presenting comparative study PRO results to clinicians and researchers: beyond the eye of the beholder. Qual Life Res 27:75-90
Woodard, Lauren E; Dennis, Cindi L; Borchers, Julie A et al. (2018) Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality. Sci Rep 8:12706
Shrestha, Eva; White, James R; Yu, Shu-Han et al. (2018) Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer. J Urol 199:161-171
Gordy, James T; Luo, Kun; Francica, Brian et al. (2018) Anti-IL-10-mediated Enhancement of Antitumor Efficacy of a Dendritic Cell-targeting MIP3?-gp100 Vaccine in the B16F10 Mouse Melanoma Model Is Dependent on Type I Interferons. J Immunother 41:181-189
El-Diwany, Ramy; Soliman, Mary; Sugawara, Sho et al. (2018) CMPK2 and BCL-G are associated with type 1 interferon-induced HIV restriction in humans. Sci Adv 4:eaat0843

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