The primary purpose of the Animal Resources Core is to facilitate cancer relevant animal projects at the Sidney Kimmel Comprehensive Cancer Center (SKCCC). The Johns Hopkins Department of Research Animal Resources oversees all laboratory animal resources and services of The Johns Hopkins University (JHU), including the SKCCC Animal Resources Core. However, due to the unique programs and goals of the SKCCC Animal Resources Core, it is managed as a separate functional unit, under the direction of the Associate Provost for Research Animal Resources and the SKCCC, and is designed specifically to enable investigator- initiated cancer therapeutic investigations in animals. The SKCCC animal care program and facilities are reviewed alongside Research Animal Resources and are fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. The SKCCC Animal Resources Core is located in two buildings: 1) the ground level of the SKCCC Cancer Research Building I (CRBI), which contains 8,069 net ft2 of space, and 2) the basement level of the SKCCC Cancer Research Building II (CRBII) which contains 29,831 net ft2 of space. Services provided include animal procurement, daily care and oversight, microbiological and sentinel monitoring, veterinary and pathology services, training and assistance with animal handling and technical procedures, maintenance of genetically altered and immunodeficient rodent breeding colonies, cross-fostering of rodent pups, and management of special facilities for the use of BSL2 and BSL3 hazardous agents. The veterinary, microbiological monitoring and pathology services are performed by the Johns Hopkins Department of Research Animal Resources on a fee-for-service basis. Cynthia Zahnow, Ph.D., Core Director, is responsible for the overall management and direction of the SKCCC Animal Resources Core. Sherrie Hawkes is Supervisor of the Animal Resources Core and is responsible for the day-to-day direction and operation of the Core. SKCCC Managed Core Reporting Period: Jan. 1, 2015, to Dec. 31, 2015

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Johns Hopkins University
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Ambinder, Richard F (2018) A viral protein kinase drug target for tumors? J Clin Invest 128:2197-2198
Lee, Alice J; Montgomery, Madeline C; Patel, Rupa R et al. (2018) Improving Insurance and Health Care Systems to Ensure Better Access to Sexually Transmitted Disease Testing and Prevention. Sex Transm Dis 45:283-286
Bharathy, Narendra; Berlow, Noah E; Wang, Eric et al. (2018) The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma. Sci Signal 11:
McGrath-Morrow, Sharon A; Ndeh, Roland; Helmin, Kathryn A et al. (2018) DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice. J Biol Chem 293:11772-11783
Huang, Peng; Park, Seyoun; Yan, Rongkai et al. (2018) Added Value of Computer-aided CT Image Features for Early Lung Cancer Diagnosis with Small Pulmonary Nodules: A Matched Case-Control Study. Radiology 286:286-295
Saung, May Tun; Muth, Stephen; Ding, Ding et al. (2018) Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer. J Immunother Cancer 6:118
Kaur, Harsimar B; Guedes, Liana B; Lu, Jiayun et al. (2018) Association of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancer. Mod Pathol 31:1539-1552
Connolly, Roisin M; Fackler, Mary Jo; Zhang, Zhe et al. (2018) Tumor and serum DNA methylation in women receiving preoperative chemotherapy with or without vorinostat in TBCRC008. Breast Cancer Res Treat 167:107-116
Ye, I Chae; Fertig, Elana J; DiGiacomo, Josh W et al. (2018) Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes. Mol Cancer Res 16:1889-1901
Zhu, Yezi; Sharp, Adam; Anderson, Courtney M et al. (2018) Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer. Eur Urol 73:727-735

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