The Pathology Core provides a comprehensive resource for human tissue-based research that takes advantage of the unique tissue resources available at the Center. Acquisition and banking of human biologic specimens to be used in studying the causes, detection, prevention and treatment of cancer has become an indelible source for supporting basic and translational cancer research in various laboratories throughout the Center. The reliability of molecular data derived from new technology platforms ultimately requires an adequate supply of optimally procured, high quality tissue specimens. The Pathology Core at MSKCC has capacity to meet this challenge and is designed as an efficient and cost-effective means to facilitate tissue use, to assist investigators with expertise in oncologic pathology and to conduct tissue-associated experimentation. The Pathology Core also serves as a national resource, as evidenced by the over 1,000 samples from multiple tumor types that have been provided to the NCI-funded Cancer Genome Atlas initiative. The Histology service within the Core facilitates selection of appropriate specimens for tissue analyses and provides basic service of cutting, dissecting and staining of fresh frozen and formalin fixed, paraffin embedded tissue. It includes construction of tissue microarray blocks and laser capture microdissection for isolation of pure cell populations and tumor cell enrichment. The Core Immunohistochemistry service provides automated and manual staining of optimized monoclonal and polyclonal antibodies to be used in clinico-pathologic correlative studies. This service also develops protocols for new antibody characterizations by using cell lines, xenograft tissue and variety of antigen retrieval and detection systems. The services and collaborative work provided by the Pathology Core has supported the research of 116 investigators in the past year. During the past grant period the work of the Core has contributed to 1320 publications of researchers from 7 research programs.

Public Health Relevance

The Pathology Core provides a comprehensive resource for human tissue-based research that takes advantage of the unique tissue resource available at the Center. The services that the Pathology Core provide are fundamental to the translational mission of the Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Skoulidis, Ferdinandos; Goldberg, Michael E; Greenawalt, Danielle M et al. (2018) STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma. Cancer Discov 8:822-835
Stolnicu, Simona; Barsan, Iulia; Hoang, Lien et al. (2018) Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas. Am J Surg Pathol 42:989-1000
Takeda, Toshikazu; Tin, Amy L; Corradi, Renato B et al. (2018) Topography of Prostate Cancer Recurrence After Radiation Therapy: A Detailed Mapping Study of Salvage Radical Prostatectomy Specimens. Eur Urol 73:488-490
Autio, Karen A; Dreicer, Robert; Anderson, Justine et al. (2018) Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer: A Phase 2 Clinical Trial. JAMA Oncol 4:1344-1351
Tseng, Jill H; Aloisi, Alessia; Sonoda, Yukio et al. (2018) Less versus more radical surgery in stage IB1 cervical cancer: A population-based study of long-term survival. Gynecol Oncol 150:44-49
Lin, Yen Hwa; Hong, Linda X; Hunt, Margie A et al. (2018) Use of a constrained hierarchical optimization dataset enhances knowledge-based planning as a quality assurance tool for prostate bed irradiation. Med Phys 45:4364-4369
Liopyris, Konstantinos; Navarrete-Dechent, Cristian; Dusza, Stephen W et al. (2018) Clinical and dermoscopic features associated with lichen planus-like keratoses that undergo skin biopsy: A single-center, observational study. Australas J Dermatol :
Yélamos, Oriol; Navarrete-Dechent, Cristián; Marchetti, Michael A et al. (2018) Clinical and dermoscopic features of cutaneous BAP1-inactivated melanocytic tumors: Results of a multicenter case-control study by the International Dermoscopy Society. J Am Acad Dermatol :
Tamura, Ryo; Pratt, Edwin C; Grimm, Jan (2018) Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging. Semin Nucl Med 48:359-366
O'Sullivan, Timothy E; Sun, Joseph C (2018) Determination of the Fate and Function of Innate Lymphoid Cells Following Adoptive Transfer of Innate Lymphoid Cell Precursors. Methods Mol Biol 1799:109-119

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