The Center of Comparative Medicine and Pathology (CCMP) supports animal model development and use through its Research Animal Resource Center (RARC) and Laboratory of Comparative Pathology (LCP). At MSKCC, animal models are used in basic and applied investigational studies as well as for training of both clinical and research staff. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer as well as the elucidation of the basic biological mechanisms resulting in neoplasia. CCMP's professional and paraprofesslonal staff (131 FTE) serve as a consultative and technical resource for MSKCC investigators on all matters related to animal research. RARC is comprised of four sections: 1) Biosecurity; 2) Education and Quality Assurance (EQA); 3) Husbandry and Operations (H&O); and 4) Veterinary Services (VS). RARC provides housing for and humane care to over 170,000 animals daily, utilized by 140 investigators. PARC's oversight of MSKCC's AAALAC-accredited, centrally managed, animal care program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the animal research program. Biosecurity ensures that MSKCC's rodent colonies remain pathogen free by routinely surveying colony health and quarantining incoming rodents from vendors. EQA administers an extensive educational program which provides training to animal care and research staff via didactic and hands-on sessions, web based tutorials as well as written instructional materials. PARC's H&O section operates three specialized state-of-the-art facilities encompassing over 80,700 net square feet of space which provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. VS's staff ensure that all animals' receive appropriate clinical care and perform technical procedures for research staff. The LCP, a multi-disciplinary pathology laboratory and its Genetically Engineered Animal (GEA) Phenotyping Service supports individual laboratory's research and PARC's programs by providing clinical and anatomic pathology services and extensive phenotypic profiles of GEA.

Public Health Relevance

The use of animal models is essential to the basic and translational research activities conducted at MSKCC. These research activities are supported and enhanced by the broad range of services and collaborative work provided by the Center of Comparative Medicine and Pathology (CCMP).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA008748-50
Application #
8986752
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2016-01-01
Budget End
2016-12-31
Support Year
50
Fiscal Year
2016
Total Cost
$2,450,521
Indirect Cost
$1,071,500
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Deng, Zengqin; Paknejad, Navid; Maksaev, Grigory et al. (2018) Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat Struct Mol Biol 25:252-260
Lee, Shih-Han; Singh, Irtisha; Tisdale, Sarah et al. (2018) Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. Nature 561:127-131
Lazarev, Stanislav; Kushner, Brian H; Wolden, Suzanne L (2018) Short Hypofractionated Radiation Therapy in Palliation of Pediatric Malignancies: Outcomes and Toxicities. Int J Radiat Oncol Biol Phys :
Kaley, Thomas; Touat, Mehdi; Subbiah, Vivek et al. (2018) BRAF Inhibition in BRAFV600-Mutant Gliomas: Results From the VE-BASKET Study. J Clin Oncol :JCO2018789990
Kiesgen, Stefan; Chicaybam, Leonardo; Chintala, Navin K et al. (2018) Chimeric Antigen Receptor (CAR) T-Cell Therapy for Thoracic Malignancies. J Thorac Oncol 13:16-26
Pak, Linda M; Kemeny, Nancy E; Capanu, Marinela et al. (2018) Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential. J Surg Oncol 117:634-643
Kunimoto, Hiroyoshi; Meydan, Cem; Nazir, Abbas et al. (2018) Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell 33:44-59.e8
Lee, Sangkyu; Kerns, Sarah; Ostrer, Harry et al. (2018) Machine Learning on a Genome-wide Association Study to Predict Late Genitourinary Toxicity After Prostate Radiation Therapy. Int J Radiat Oncol Biol Phys 101:128-135
Speranza, Giovanna; Anderson, Larry; Chen, Alice P et al. (2018) First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile. Invest New Drugs 36:230-239
Pratt, Edwin C; Shaffer, Travis M; Zhang, Qize et al. (2018) Nanoparticles as multimodal photon transducers of ionizing radiation. Nat Nanotechnol 13:418-426

Showing the most recent 10 out of 8799 publications