The Behavioral Research Methods (BRM) Core Facility enhances the scientific objectives of the Center's programs by assisting MSKCC investigators with the design, implementation and execution of research involving the capture of health-related quality-of-life (HRQoL) and/or patient-reported outcome (PRO) data. The faculty of the BRM Core are nationally recognized social and behavioral sciences experts who provide technical assistance to all users throughout their various stages of research, including grant and protocol development, research study assistant and support staff training, and sample identification. The BRM Core Facility assists investigators by providing the following specific services and technical support functions: 1) selection, analysis, and interpretation of psychometrically sound assessment tools (provider surveys, semi-structured interviews, patient-reporting instruments, and observer ratings) for the measurement of quality of life, health behavior change, treatment toxicities, and other psychosocial outcomes; 2) consultation regarding the development and implementation of research methodologies consistent with best practices in psychosocial and behavioral research in cancer; 3) qualitative Interview, focus group methodology, and other process evaluation techniques for developing new psychosocial instruments and generating new testable hypotheses; 4) training and trouble-shooting with regard to patient Interviewing methods, survey data collection, and human subjects' issues for research support staff conducting quality of life and behavioral/psychosocial studies; and 5) methodological support for research on minority populations in clinical trials, community interventions, and population-based research. The BRM Core Facility maintains an extensive resource library of electronic psychosocial and behavioral measures and research method protocols commonly used in cancer prevention and control research. The services provided by the BRM Core have supported the research of 20 investigators in the past year. During the past grant period the work Of the Core has contributed to 190 publications of researchers.

Public Health Relevance

Methodological advances in the behavioral and social sciences are widely recognized as germane to translational research in cancer prevention, early detection, treatment, palliative care, and survivorship. Additionally, the NCI and the FDA acknowledge that patient-reported outcome data is the gold standard for the capture of the patient experience.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA008748-51
Application #
9204772
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2017-01-01
Budget End
2017-12-31
Support Year
51
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Yang, Annie; Baxi, Shrujal; Korenstein, Deborah (2018) ClinicalTrials.gov for Facilitating Rapid Understanding of Potential Harms of New Drugs: The Case of Checkpoint Inhibitors. J Oncol Pract 14:72-76
Mikropoulos, Christos; Selkirk, Christina G Hutten; Saya, Sibel et al. (2018) Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. Br J Cancer 118:266-276
Takpradit, Chayamon; Prockop, Susan E; Kernan, Nancy A et al. (2018) Allogeneic Matched Related Donor Bone Marrow Transplantation for Pediatric Patients With Severe Aplastic Anemia Using ""Low-dose"" Cyclophosphamide, ATG Plus Fludarabine. J Pediatr Hematol Oncol 40:e220-e224
Katz, Steven J; Jagsi, Reshma; Morrow, Monica (2018) Reducing Overtreatment of Cancer With Precision Medicine: Just What the Doctor Ordered. JAMA 319:1091-1092
Konishi, Tsuyoshi; Shimada, Yoshifumi; Lee, Lik Hang et al. (2018) Poorly Differentiated Clusters Predict Colon Cancer Recurrence: An In-Depth Comparative Analysis of Invasive-Front Prognostic Markers. Am J Surg Pathol 42:705-714
Teixeira, Ricardo João; Applebaum, Allison J; Bhatia, Sangeeta et al. (2018) The impact of coping strategies of cancer caregivers on psychophysiological outcomes: an integrative review. Psychol Res Behav Manag 11:207-215
Powles, Ryan L; Redmond, David; Sotiriou, Christos et al. (2018) Association of T-Cell Receptor Repertoire Use With Response to Combined Trastuzumab-Lapatinib Treatment of HER2-Positive Breast Cancer: Secondary Analysis of the NeoALTTO Randomized Clinical Trial. JAMA Oncol 4:e181564
Querfeld, Christiane; Leung, Samantha; Myskowski, Patricia L et al. (2018) Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile. Cancer Immunol Res 6:900-909
Rafiq, Sarwish; Yeku, Oladapo O; Jackson, Hollie J et al. (2018) Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo. Nat Biotechnol 36:847-856
Francis, Jasmine H; Roosipu, Nelli; Levin, Ariana M et al. (2018) Current Treatment of Bilateral Retinoblastoma: The Impact of Intraarterial and Intravitreous Chemotherapy. Neoplasia 20:757-763

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