The goal of Structural Biology (SB) Core (formerly X-Ray Crystallography Core) is to provide access to expertise as well as state-of-the-art equipment and software to Center laboratories that address structural questions within their research. Understanding the biological processes involved in tumorigenesis has increasingly benefitted from structural investigations that provide key functional and mechanistic insights, as well as atomic-level details important for drug discovery. Many of the questions require the structure determination of large proteins, assemblies and macromolecular machines. The Core maintains in house equipment (Rigaku Micromax 007hf diffractometer and Titan Krios-Gatan K2 cryo electron microscope) and computational resources for data collection, processing and structure determination, including graphical workstations and a high-performance Linux cluster. The SB Core implements a range of software packages for structural determination and analysis, participates in multi-institutional consortia for access to synchrotron beamlines and cryoEM and provides training and assistance to users. In addition, the Core Head collaborates with non-structural MSK groups on macromolecular crystallization and structure-determination projects, and also provides modeling expertise and guidance to those labs that can benefit from the use of available structures in the design and interpretation of experiments. The SB Core has supported 9 investigators in the past year and has contributed to 127 publications of investigators from 3 programs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Tamura, Ryo; Pratt, Edwin C; Grimm, Jan (2018) Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging. Semin Nucl Med 48:359-366
O'Sullivan, Timothy E; Sun, Joseph C (2018) Determination of the Fate and Function of Innate Lymphoid Cells Following Adoptive Transfer of Innate Lymphoid Cell Precursors. Methods Mol Biol 1799:109-119
Salo-Mullen, Erin E; Lynn, Patricio B; Wang, Lu et al. (2018) Contiguous gene deletion of chromosome 2p16.3-p21 as a cause of Lynch syndrome. Fam Cancer 17:71-77
Sigel, Carlie S; Krauss Silva, Vitor Werneck; Reid, Michelle D et al. (2018) Assessment of cytologic differentiation in high-grade pancreatic neuroendocrine neoplasms: A multi-institutional study. Cancer Cytopathol 126:44-53
Sauter, Craig S; Matasar, Matthew J; Schoder, Heiko et al. (2018) A phase 1 study of ibrutinib in combination with R-ICE in patients with relapsed or primary refractory DLBCL. Blood 131:1805-1808
Berry, Sean L; Tierney, Kevin P; Elguindi, Sharif et al. (2018) Five years' experience with a customized electronic checklist for radiation therapy planning quality assurance in a multicampus institution. Pract Radiat Oncol 8:279-286
Breitbart, William (2018) Jimmie C. Holland, M.D. Psychosomatics 59:123-124
Geller, Shamir; Pitter, Ken; Moskowitz, Alison et al. (2018) Treatment of Vulvar Mycosis Fungoides Tumors With Localized Radiotherapy. Clin Lymphoma Myeloma Leuk 18:e279-e281
Romesser, Paul B; Pei, Xin; Shi, Weiji et al. (2018) Prostate-Specific Antigen (PSA) Bounce After Dose-Escalated External Beam Radiation Therapy Is an Independent Predictor of PSA Recurrence, Metastasis, and Survival in Prostate Adenocarcinoma Patients. Int J Radiat Oncol Biol Phys 100:59-67
Ankerst, Donna P; Straubinger, Johanna; Selig, Katharina et al. (2018) A Contemporary Prostate Biopsy Risk Calculator Based on Multiple Heterogeneous Cohorts. Eur Urol 74:197-203

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