The goal of Structural Biology (SB) Core (formerly X-Ray Crystallography Core) is to provide access to expertise as well as state-of-the-art equipment and software to Center laboratories that address structural questions within their research. Understanding the biological processes involved in tumorigenesis has increasingly benefitted from structural investigations that provide key functional and mechanistic insights, as well as atomic-level details important for drug discovery. Many of the questions require the structure determination of large proteins, assemblies and macromolecular machines. The Core maintains in house equipment (Rigaku Micromax 007hf diffractometer and Titan Krios-Gatan K2 cryo electron microscope) and computational resources for data collection, processing and structure determination, including graphical workstations and a high-performance Linux cluster. The SB Core implements a range of software packages for structural determination and analysis, participates in multi-institutional consortia for access to synchrotron beamlines and cryoEM and provides training and assistance to users. In addition, the Core Head collaborates with non-structural MSK groups on macromolecular crystallization and structure-determination projects, and also provides modeling expertise and guidance to those labs that can benefit from the use of available structures in the design and interpretation of experiments. The SB Core has supported 9 investigators in the past year and has contributed to 127 publications of investigators from 3 programs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Deng, Pujuan; Zhou, Yuqiao; Jiang, Junyi et al. (2018) Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology. Proc Natl Acad Sci U S A 115:9998-10003
Bellelli, Roberto; Vitagliano, Donata; Federico, Giorgia et al. (2018) Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia. Mol Cell Endocrinol 460:24-35
Signoretti, Sabina; Flaifel, Abdallah; Chen, Ying-Bei et al. (2018) Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers. J Clin Oncol :JCO2018792259
D'Agostino, Thomas A; Shuk, Elyse; Maloney, Erin K et al. (2018) Treatment decision making in early-stage papillary thyroid cancer. Psychooncology 27:61-68
Turcot, Valérie (see original citation for additional authors) (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 50:26-41
Moryl, Natalie; Dave, Vinnidhy; Glare, Paul et al. (2018) Patient-Reported Outcomes and Opioid Use by Outpatient Cancer Patients. J Pain 19:278-290
Vickers, Andrew J; Vertosick, Emily A; Lewith, George et al. (2018) Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. J Pain 19:455-474
Muhsen, Shirin; Moo, Tracy-Ann; Patil, Sujata et al. (2018) Most Breast Cancer Patients with T1-2 Tumors and One to Three Positive Lymph Nodes Do Not Need Postmastectomy Radiotherapy. Ann Surg Oncol 25:1912-1920
Gupta, Piyush; Migliacci, Jocelyn C; Montero, Pablo H et al. (2018) Do we need a different staging system for tongue and gingivobuccal complex squamous cell cancers? Oral Oncol 78:64-71
Giri, Veda N; Knudsen, Karen E; Kelly, William K et al. (2018) Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017. J Clin Oncol 36:414-424

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