The Animal Imaging Core provides individual projects with non-invasive, high-resolution quantitative imaging- based capabilities for metabolic, phenotypic, and genetic characterization of tumors and their microenvironment, including in vivo trafficking of tumor cells for rodent models of human cancer. This is accomplished by monitoring of ?directly-targeting? probes and of the expression of single-and multi-modality reporter genes using optical (bioluminescence and fluorescence), radionuclide (PET, SPECT, and autoradiography), MRI/MRS, CT, and US imaging. These non-invasive imaging techniques have long been established at MSK for small-animal imaging studies, are quantitative and thus readily adaptable to longitudinal studies. Co-localization of all animal imaging capabilites within the ZRC vivarium provides enhanced biosecurity and functionality and houses the Core?s Focus 120 microPET and Imveon microPET/microCT, Ivis Spectrum and Spectrum CT optical imaging systems NanoSPECT/CT Plu, and Vevo 2100 ultrasound system. The Ivis 100 optical imaging system has been upgraded to a Lumina II system and remains on the 12th floor of the Rockefeller Research Laboratory to provide ready access for investigators in that building. A new isocentric, image (CT)-guided microirradiator, the X-RAD 225Cx Image-Guided Biological Irradiator, for precise (down to 1-mm3) therapeutic irradiation of rodent tumors and other structures provides investigators with clinical-grade radiotherapy capability in terms of spatial accuracy and precision of dose delivery. The Core?s 7.0T 30-cm boreBruker NMR imaging and spectroscopy systems is within the ZRC Vivarium. The new PET insert (funded by RC2CA14897), which the Core recently received is compatible with the 7T magnet and is in current use. Additionally, the Core has an 11.7T vertical magnet and will shortly accept a new 9.4T magnet (funded by 1S10 OD023669) with an updated console (AV3) to replace the old 4.7T MR system) to be installed in this space as well. The Core also provides investigators with access to critical ancillary equipment and services such as a Fuji Film BAS-1800II phosphor-plate digital autoradiography system, a digital-camera- equipped Olympus B 201 fluorescence microscope with motorized stage, and a Microm HM500M cryostatic microtome and software such as SAAM II for linear and non-linear compartmental modeling, PMOD for voxel- based compartmental modeling/ parametric imaging, and OLINDA for internal radionuclide radiation dosimetry. The scientific value and cost-effectiveness of this state-of-the-art Animal Imaging Core is documented by the following (among other metrics): nearly 500 peer-reviewed Core-supported publications from 2013-2017 and 9 major instruments purchased with funding support provided by NIH and other Shared Instrumentation grants.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA008748-55
Application #
10084818
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-20
Project End
2023-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
55
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Deng, Pujuan; Zhou, Yuqiao; Jiang, Junyi et al. (2018) Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology. Proc Natl Acad Sci U S A 115:9998-10003
Bellelli, Roberto; Vitagliano, Donata; Federico, Giorgia et al. (2018) Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia. Mol Cell Endocrinol 460:24-35
Signoretti, Sabina; Flaifel, Abdallah; Chen, Ying-Bei et al. (2018) Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers. J Clin Oncol :JCO2018792259
D'Agostino, Thomas A; Shuk, Elyse; Maloney, Erin K et al. (2018) Treatment decision making in early-stage papillary thyroid cancer. Psychooncology 27:61-68
Turcot, Valérie (see original citation for additional authors) (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 50:26-41
Moryl, Natalie; Dave, Vinnidhy; Glare, Paul et al. (2018) Patient-Reported Outcomes and Opioid Use by Outpatient Cancer Patients. J Pain 19:278-290
Vickers, Andrew J; Vertosick, Emily A; Lewith, George et al. (2018) Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. J Pain 19:455-474
Muhsen, Shirin; Moo, Tracy-Ann; Patil, Sujata et al. (2018) Most Breast Cancer Patients with T1-2 Tumors and One to Three Positive Lymph Nodes Do Not Need Postmastectomy Radiotherapy. Ann Surg Oncol 25:1912-1920
Gupta, Piyush; Migliacci, Jocelyn C; Montero, Pablo H et al. (2018) Do we need a different staging system for tongue and gingivobuccal complex squamous cell cancers? Oral Oncol 78:64-71
Giri, Veda N; Knudsen, Karen E; Kelly, William K et al. (2018) Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017. J Clin Oncol 36:414-424

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