The Pathology Core is an integral pillar of the MSK Precision Pathology Biobanking Center and provides a comprehensive resource for human tissue-based research that takes advantage of the unique tissue resources available at MSK. The acquisition and banking of human biologic specimens to be used to study causes, detection, prevention, and treatment of cancer have become an indispensible resource for basic and translational cancer researchers throughout MSK. The reliability of molecular data derived from new technology platforms depends on access to an adequate supply of optimally procured, high-quality tissue specimens. The Pathology Core at MSK provides efficient and cost-effective services to facilitate tissue use and to conduct human biospecimen-based experimentation. The Core also serves as a national resource, as evidenced by the over 1,000 samples from multiple tumor types that have been provided to the NCI-funded TCGA initiative, as well as the samples that will be contributed to the NCI?s CPTAC proteogenomics consortium. The Histology Service within the Core facilitates selection of appropriate specimens for tissue analyses and provides the basic services of cutting, dissecting, and staining of fresh-frozen and formalin-fixed, paraffin- embedded tissues. It includes construction of tissue microarray blocks and laser capture microdissection for isolation of pure cell populations and tumor cell enrichment. The Core?s Immunohistochemistry Service provides automated and manual staining using optimized monoclonal and polyclonal antibodies to be used in clinico-pathologic research studies. The service also continuously develops and optimizes protocols for new antibodies and for a variety of sensitive detection systems. The services and collaborative work provided by the Pathology Core have contributed to 1,685 publications of MSK researchers from nine of the 10 Center Programs. Many of these papers were published in leading cancer and general interest journals.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA008748-55
Application #
10084822
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-20
Project End
2023-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
55
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Assel, Melissa J; Li, Fan; Wang, Ying et al. (2018) Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration: Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study. Ophthalmology 125:391-397
Rebbeck, Timothy R (see original citation for additional authors) (2018) Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. Hum Mutat 39:593-620
Yeung, K Simon; Hernandez, Marisol; Mao, Jun J et al. (2018) Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phytother Res 32:865-891
Audenet, Fran├žois; Vertosick, Emily A; Fine, Samson W et al. (2018) Biopsy Core Features are Poor Predictors of Adverse Pathology in Men with Grade Group 1 Prostate Cancer. J Urol 199:961-968
Petrovic, Ivana; Rosen, Evan B; Matros, Evan et al. (2018) Oral rehabilitation of the cancer patient: A formidable challenge. J Surg Oncol 117:1729-1735
Balakrishnan, Mridula; Baylies, Mary K (2018) Myonuclear Positioning and Aneurysms Are LINC'd by Ariande. Dev Cell 45:149-150
McKnight, Brooke N; Kuda-Wedagedara, Akhila N W; Sevak, Kuntal K et al. (2018) Imaging EGFR and HER3 through 89Zr-labeled MEHD7945A (Duligotuzumab). Sci Rep 8:9043
Thor, Maria; Jackson, Andrew; Zelefsky, Michael J et al. (2018) Inter-institutional analysis demonstrates the importance of lower than previously anticipated dose regions to prevent late rectal bleeding following prostate radiotherapy. Radiother Oncol 127:88-95
Wiener, Lori; Rosenberg, Abby R; Lichtenthal, Wendy G et al. (2018) Personalized and yet standardized: An informed approach to the integration of bereavement care in pediatric oncology settings. Palliat Support Care 16:706-711
Damaskos, Penny; Amaya, Beau; Gordon, RuthAnn et al. (2018) Intersectionality and the LGBT Cancer Patient. Semin Oncol Nurs 34:30-36

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