The Radiochemistry and Molecular Imaging Probes (RMIP) Core functions at the intersection of the Cancer Center's laboratory research and clinical molecular imaging initiatives?including cancer biology, medicine, chemistry, physics, radiochemistry, pharmacology, and engineering, and is one of the largest manufacturing units at MSK in terms of the number of clinical and research products produced. The RMIP Core was established to provide investigators with radionuclides and to incorporate these radionuclides into radiolabeled diagnostic and/or therapeutic pharmaceuticals for both basic research investigations and patient formulations. The RMIP Core consists of 5 major elements working closely together to provide the following services: the Cyclotron Facility, the Small Molecule Radiochemistry Section, the Antibody Labeling Section, the Development and Clinical Translation Section and the Hyperpolarized Magnetic Resonance Section. MSK and the RMIP Core have an outstanding reputation for supporting clinical translation of both imaging and therapeutic agents. Specifically, with regard to the translation of radiopharmaceuticals, over the past 20 years, the RMIP Core has produced > 45 radiopharmaceuticals and molecular imaging agents for research clinical trials (imaging and therapy) in humans with radiolabeled antibodies, small molecules, nanoparticles and radiotherapeutics.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Karimov, Rashad R; Tan, Derek S; Gin, David Y (2018) Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction. Tetrahedron 74:3370-3383
Fass, Josh; Sivak, David A; Crooks, Gavin E et al. (2018) Quantifying Configuration-Sampling Error in Langevin Simulations of Complex Molecular Systems. Entropy (Basel) 20:
Mauguen, Audrey; Seshan, Venkatraman E; Ostrovnaya, Irina et al. (2018) Estimating the probability of clonal relatedness of pairs of tumors in cancer patients. Biometrics 74:321-330
Tanner, Edward J; Filippova, Olga T; Gardner, Ginger J et al. (2018) A prospective trial of acute normovolemic hemodilution in patients undergoing primary cytoreductive surgery for advanced ovarian cancer. Gynecol Oncol 151:433-437
Arbour, Kathryn C; Kris, Mark G; Riely, Gregory J et al. (2018) Twice weekly pulse and daily continuous-dose erlotinib as initial treatment for patients with epidermal growth factor receptor-mutant lung cancers and brain metastases. Cancer 124:105-109
Soslow, Robert A; Murali, Rajmohan (2018) A guided tour of selected issues pertaining to metastatic carcinomas involving or originating from the gynecologic tract. Semin Diagn Pathol 35:95-107
Kao, Yu-Chien; Owosho, Adepitan A; Sung, Yun-Shao et al. (2018) BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas. Am J Surg Pathol 42:604-615
Knight, Julia A; Blackmore, Kristina M; Fan, Jing et al. (2018) The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study. Breast Cancer Res 20:23
Nashat, Melissa A; Ricart Arbona, Rodolfo J; Riedel, Elyn R et al. (2018) Comparison of Diagnostic Methods and Sampling Sites for the Detection of Demodex musculi. J Am Assoc Lab Anim Sci 57:173-185
Roth, Allen J; Shuman, Stewart; Schwer, Beate (2018) Defining essential elements and genetic interactions of the yeast Lsm2-8 ring and demonstration that essentiality of Lsm2-8 is bypassed via overexpression of U6 snRNA or the U6 snRNP subunit Prp24. RNA 24:853-864

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