The Radiochemistry and Molecular Imaging Probes (RMIP) Core functions at the intersection of the Cancer Center's laboratory research and clinical molecular imaging initiatives?including cancer biology, medicine, chemistry, physics, radiochemistry, pharmacology, and engineering, and is one of the largest manufacturing units at MSK in terms of the number of clinical and research products produced. The RMIP Core was established to provide investigators with radionuclides and to incorporate these radionuclides into radiolabeled diagnostic and/or therapeutic pharmaceuticals for both basic research investigations and patient formulations. The RMIP Core consists of 5 major elements working closely together to provide the following services: the Cyclotron Facility, the Small Molecule Radiochemistry Section, the Antibody Labeling Section, the Development and Clinical Translation Section and the Hyperpolarized Magnetic Resonance Section. MSK and the RMIP Core have an outstanding reputation for supporting clinical translation of both imaging and therapeutic agents. Specifically, with regard to the translation of radiopharmaceuticals, over the past 20 years, the RMIP Core has produced > 45 radiopharmaceuticals and molecular imaging agents for research clinical trials (imaging and therapy) in humans with radiolabeled antibodies, small molecules, nanoparticles and radiotherapeutics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA008748-55
Application #
10084825
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-20
Project End
2023-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
55
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Karimov, Rashad R; Tan, Derek S; Gin, David Y (2018) Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction. Tetrahedron 74:3370-3383
Fass, Josh; Sivak, David A; Crooks, Gavin E et al. (2018) Quantifying Configuration-Sampling Error in Langevin Simulations of Complex Molecular Systems. Entropy (Basel) 20:
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Roth, Allen J; Shuman, Stewart; Schwer, Beate (2018) Defining essential elements and genetic interactions of the yeast Lsm2-8 ring and demonstration that essentiality of Lsm2-8 is bypassed via overexpression of U6 snRNA or the U6 snRNP subunit Prp24. RNA 24:853-864

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