This program concerns the genetics, biology and virology of cancer. New major developments in our understanding of the mechanisms of malignant transformation have resulted from the investigations carried out at The Wistar Institute. The role of specific oncogenes in the pathogenesis of leukemias and lymphomas in man has been assessed and the mechanisms of their activation have been determined. In addition, very recently it has been possible to establish that the gene for the alpha chain of the T cell receptor may have an important role in oncogene activation in human T cell leukemia. New oncogenes involved in hematopoietic malignancies have been identified, cloned and characterized. In addition new breakthroughs have been achieved in the area of nuclear transfer into fertilized eggs. The extremely high rate of success in this type of experiment opens new avenues in our ability to understand mammalian development and to investigate the role of cytoplasmic nuclear factors during early embryogenesis.
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| Seo, Jae Ho; Agarwal, Ekta; Bryant, Kelly G et al. (2018) Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements. Cancer Res 78:4215-4228 |
| Lu, Huimin; Bowler, Nicholas; Harshyne, Larry A et al. (2018) Exosomal ?v?6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biol 70:20-35 |
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| Papasavvas, Emmanouil; Lada, Steven M; Joseph, Jocelin et al. (2018) Analytical ART interruption does not irreversibly change pre-interruption levels of cellular HIV. AIDS : |
| Reyes-Uribe, Patricia; Adrianzen-Ruesta, Maria Paz; Deng, Zhong et al. (2018) Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma. Oncogene 37:4058-4072 |
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