The goal of the High Resolution Imaging Shared Facility (HRISF) is to enable the detection and imaging of molecules in biological systems, which is a vital tool in cancer research .To accomplish this mission, the facility provides access to instrumentation and expertise that supports both fundamental mechanistic studies, and the development and testing of new biomarkers and treatments for cancer. The HRISF was founded in the late 1990s with funds from an NCRR Shared Instrument Grant, a UAB Health Services Foundation award, and significant institutional resources.
The specific aims of the HRISF are: 1) To provide consultation in the design and conduct of Confocal Laser Scanning Microscopy (CLSM),Multi-platform Laser Scanning Microscopy (MPLSM), and digital imaging experiments 2) To provide technical assistance for imaging studies, including consultation concerning specimen preparation, and assistance with image acquisition. 3) To provide assistance in post-acquisition data analysis and interpretation. 4) To work with members of the CCC to identify new ways that these imaging technologies can be employed to enhance their research productivity and overall competitiveness. 5) To adapt sophisticated new imaging techniques, including fluorescence lifetime measurements and 2""""""""""""""""^ harmonic generation, to the research problems of CCC members. Many of the instruments required to image molecules at the sub-cellular level would require an investment in expensive equipment and in expertise that generally lie outside the capabilities of any single laboratory. A centralized facility provides access both to cutting-edge technology to acquire images and to personnel with the experience to guide CCC investigators in optimal use of the technology. The HRISF served 55 CCC investigators during the current funding period and their use accounted for 46% of the total facility usage. During this same period, support from the CCC accounted for less than 23% of the total annual operating costs of the facility.

Public Health Relevance

To understand the fundamental mechanisms of the biology of cancer cells, it is important to be able to determine the precise location and behavior of the proteins inside the cells. The High Resolution Imaging Facility provides instrumentation and expertise to support fundamental mechanistic studies of cancer biology. Furthermore, the facility resources support the identification of new biomarkers that are essential for cancer diagnosis and for the development of novel treatments for cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013148-42
Application #
8738170
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
42
Fiscal Year
2014
Total Cost
$137,241
Indirect Cost
$63,251
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Leath 3rd, Charles A; Monk, Bradley J (2018) Twenty-first century cervical cancer management: A historical perspective of the gynecologic oncology group/NRG oncology over the past twenty years. Gynecol Oncol 150:391-397
Park, Misun; Yoon, Young Sup (2018) Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes. Korean Circ J 48:974-988
Toboni, Michael D; Smith, Haller J; Bae, Sejong et al. (2018) Predictors of Unplanned Reoperation for Ovarian Cancer Patients From the National Surgical Quality Improvement Program Database. Int J Gynecol Cancer 28:1427-1431
Dionne-Odom, J Nicholas; Applebaum, Allison J; Ornstein, Katherine A et al. (2018) Participation and interest in support services among family caregivers of older adults with cancer. Psychooncology 27:969-976
Demark-Wahnefried, Wendy; Schmitz, Kathryn H; Alfano, Catherine M et al. (2018) Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin 68:64-89
Bandari, Shyam K; Purushothaman, Anurag; Ramani, Vishnu C et al. (2018) Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior. Matrix Biol 65:104-118
Gowda, Pramod S; Wildman, Benjamin J; Trotter, Timothy N et al. (2018) Runx2 Suppression by miR-342 and miR-363 Inhibits Multiple Myeloma Progression. Mol Cancer Res 16:1138-1148
Dix, Daniel B; McDonald, Andrew M; Gordetsky, Jennifer B et al. (2018) How Would MRI-targeted Prostate Biopsy Alter Radiation Therapy Approaches in Treating Prostate Cancer? Urology 122:139-146
Prince, Andrew C; Moore, Lindsay S; Tipirneni, Kiranya E et al. (2018) Evaluation of optical imaging agents in a fluorescence-guided surgical model of head and neck cancer. Surg Oncol 27:225-230
Gangrade, Abhishek; Pathak, Vibha; Augelli-Szafran, Corinne E et al. (2018) Preferential Inhibition of Wnt/?-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer. Int J Mol Sci 19:

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