MOLECULAR ANALYSIS / TRANSLATION RESEARCH GROUP MICROBIOME / GNOTOBIOTIC SHARED FACILITY (MGSF) ABSTRACT The overall goal of the new UAB-CCC Microbiome/Gnotobiotics Shared Facility (MGSF) is to provide UAB- CCC investigators with access to cutting-edge microbiome analysis methodologies and gnotobiotic animal models designed to facilitate and strengthen the quality of CCC-related research. A pilot UAB-CCC Microbiome/Gnotobiotic Shared Facility (MGSF) was started in February 2012 in response to the role that microbial pathogens play in metabolism and energetics that link obesity and cancer, which are major health concerns in UAB CCC catchment area and the entire Southeast. Understanding the role of the microbiome in cancer requires investigation of the interactions among genes of the microbiota and host. Essential to such research is the ability to manipulate and define the microbiota, i.e., develop defined-flora and ?humanized? animal models. Gnotobiotic mice transplantation provides a unique advantage to UAB-CCC investigators to study disease links and health implications of differences identified from the microbiome analysis (including metagenome analysis). The following Specific Aims are proposed: 1. To provide state-of-the-art microbiome analysis services to CCC investigators. 2. To provide computational bioinformatics expertise to assist UAB-CCC investigators in the analysis and understanding of microbiome data. 3. To provide gnotobiotic animal services to CCC investigators. 4. Education and Outreach.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013148-48
Application #
9895642
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
48
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Carson, Tiffany L; Wang, Fuchenchu; Cui, Xiangqin et al. (2018) Associations Between Race, Perceived Psychological Stress, and the Gut Microbiota in a Sample of Generally Healthy Black and White Women: A Pilot Study on the Role of Race and Perceived Psychological Stress. Psychosom Med 80:640-648
Williams, Adele P; Waters, Alicia M; Stewart, Jerry E et al. (2018) A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro. J Surg Res 228:54-62
Frugé, Andrew D; Cases, Mallory G; Howell, Carrie R et al. (2018) Fingernail and toenail clippings as a non-invasive measure of chronic cortisol levels in adult cancer survivors. Cancer Causes Control 29:185-191
McCaw, Tyler R; Randall, Troy D; Arend, Rebecca C (2018) Overcoming immune suppression with epigenetic modification in ovarian cancer. Transl Res :
Geng, Mengxin; Austin, Frank; Shin, Ronald et al. (2018) Covalent Structure and Bioactivity of the Type AII Lantibiotic Salivaricin A2. Appl Environ Microbiol 84:
Samykutty, Abhilash; Grizzle, William E; Fouts, Benjamin L et al. (2018) Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle. Biomaterials 182:114-126
Friedman, Gregory K; Bernstock, Joshua D; Chen, Dongquan et al. (2018) Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression. Sci Rep 8:13930
Powell, T Clark; Dilley, Sarah E; Bae, Sejong et al. (2018) The Impact of Racial, Geographic, and Socioeconomic Risk Factors on the Development of Advanced-Stage Cervical Cancer. J Low Genit Tract Dis 22:269-273
Kasten, Benjamin B; Oliver, Patsy G; Kim, Harrison et al. (2018) 212Pb-Labeled Antibody 225.28 Targeted to Chondroitin Sulfate Proteoglycan 4 for Triple-Negative Breast Cancer Therapy in Mouse Models. Int J Mol Sci 19:
Subramaniam, Akila; Blanchard, Christina T; Erickson, Britt K et al. (2018) Feasibility of Complete Salpingectomy Compared With Standard Postpartum Tubal Ligation at Cesarean Delivery: A Randomized Controlled Trial. Obstet Gynecol 132:20-27

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