Abstract

The Genome Imaging Shared Resource (GISR) is a new shared resource developed since the last CCSGreview. The facility provides tools for cytogenetic analysis of the entire genome as well as specific probestargeted to regions of interest. These include fluorescent in situ hybridization (FISH) with locus specificprobes (LSP) generated 'in house', specifically designed and labeled based upon the experimentalrequirements. Spectral Karyotyping (SKY) and whole chromosome painting for human and mouse samplesare also part of the service. This facility was initiated in late 2004 with the recruitment of Cristina Montagnafrom Thomas Ried's laboratory from the NCI. The GISR is not a high-volume facility and, because it wasinaugurated only recently, the scope of usage is smaller than for most AECC shared resources. However,this facility provides a very important technology and service to AECC investigators and will play a criticalrole in the growing genomics and, in particular, epigenetics research activities at the Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA013330-35
Application #
7506852
Study Section
Subcommittee G - Education (NCI)
Project Start
2007-09-25
Project End
2012-06-30
Budget Start
2007-09-25
Budget End
2008-06-30
Support Year
35
Fiscal Year
2007
Total Cost
$93,522
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Van Arsdale, Anne R; Arend, Rebecca C; Cossio, Maria J et al. (2018) Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma. Cancer Med 7:616-625
Ruiz, Penelope D; Gamble, Matthew J (2018) MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20. Nat Commun 9:5143
Rohan, Thomas; Ye, Kenny; Wang, Yihong et al. (2018) MicroRNA expression in benign breast tissue and risk of subsequent invasive breast cancer. PLoS One 13:e0191814
Walters, Ryan O; Arias, Esperanza; Diaz, Antonio et al. (2018) Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Rep 25:663-676.e6
Racine, Jeremy J; Stewart, Isabel; Ratiu, Jeremy et al. (2018) Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes 67:923-935
Frimer, Marina; Miller, Eirwen M; Shankar, Viswanathan et al. (2018) Adjuvant Pelvic Radiation ""Sandwiched"" Between Paclitaxel/Carboplatin Chemotherapy in Women With Completely Resected Uterine Serous Carcinoma: Long-term Follow-up of a Prospective Phase 2 Trial. Int J Gynecol Cancer 28:1781-1788
Kale, Abhijit; Ji, Zhejun; Kiparaki, Marianthi et al. (2018) Ribosomal Protein S12e Has a Distinct Function in Cell Competition. Dev Cell 44:42-55.e4
Lee, Chang-Hyun; Kiparaki, Marianthi; Blanco, Jorge et al. (2018) A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition. Dev Cell 46:456-469.e4
Mao, Serena P H; Park, Minji; Cabrera, Ramon M et al. (2018) Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res 20:131
Mocholi, Enric; Dowling, Samuel D; Botbol, Yair et al. (2018) Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy. Cell Rep 24:1136-1150

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