The Animal Barrier Shared Resource (ABSR) supports the mission of the AECC by providing an environment in which the highest quality of animal research studies can be conducted while maintaining the highest standards of animal care and animal welfare. A major objective of the ABSR is to maintain the health quality of barrier housed specific pathogen-free (SPF) mice, keeping them free of adventitious murine infectious agents that could disrupt breeding or confound research results. Barrier housing is provided for SPF mice while permitting supervised access for investigators. AECC investigators maintain breeding colonies either to expand novel strains bearing transgene or targeted mutations from genetically-manipulated founder animals, or to recombine several specific alleles from different genetic loci into a limited set of genotypes on a single strain background. Frequent convenient access is crucial for investigators so that they may set up matings, collect tissue biopsies from successive litters for genotype determination, and observe animals for physical and behavioral characteristics (phenotype), specifically, their propensity to develop neoplasia. In addition, many AECC investigators use specific pathogen-free rodents that either have a genetic predisposition to develop spontaneous neoplasia or are immunodeficient and tolerate tumor xenografts as models to study specific processes such as angiogenesis and metastasis and for testing antineoplastic therapies. These investigators must have frequent access to their animals to implant tumor tissues, monitor tumor growth, administer various treatments, and collect tissue biopsies. Animal husbandry services, veterinary care, and comprehensive rodent quality assurance and quarantine programs are provided to the AECC by the Institute of Animal Studies (IAS). The IAS consists of three faculty Laboratory Animal Veterinarians (including the Director), three Veterinary Technicians, a staff of approximately 40 Animal Caretakers, a Facilities Manager, two Husbandry Supervisors, as well as office administrative staff. In addition to providing veterinary care, the IAS veterinarians also provide oversight of the animal care and use program, monitor regulatory compliance, and conduct small-group and individual training sessions for investigators. Pathology diagnostic services are provided by a Veterinary Pathologist who also directs the Histopathology Shared Resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013330-37
Application #
7886683
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
37
Fiscal Year
2009
Total Cost
$280,673
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Zamurrad, Sumaira; Hatch, Hayden A M; Drelon, Coralie et al. (2018) A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5. Cell Rep 22:2359-2369
Sparano, Joseph A (2018) Prognostic gene expression assays in breast cancer: are two better than one? NPJ Breast Cancer 4:11
Centini, Ryan; Tsang, Mark; Iwata, Terri et al. (2018) Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation. PLoS One 13:e0197973
Nadaradjane, Celine; Yang, Chia-Ping Huang; Rodriguez-Gabin, Alicia et al. (2018) Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners. J Nat Prod 81:607-615
Tiwari, Sangeeta; van Tonder, Andries J; Vilchèze, Catherine et al. (2018) Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 115:9779-9784
Celestrin, Kevin; Díaz-Balzac, Carlos A; Tang, Leo T H et al. (2018) Four specific immunoglobulin domains in UNC-52/Perlecan function with NID-1/Nidogen during dendrite morphogenesis in Caenorhabditis elegans. Development 145:
Haider, Afreen; Wei, Yu-Chen; Lim, Koini et al. (2018) PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress. Dev Cell 45:481-495.e8
Cai, Ying; Lin, Jhih-Rong; Zhang, Quanwei et al. (2018) Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer. Sci Rep 8:5535
Li, Ke; Baker, Nicholas E (2018) Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners. Elife 7:
Xie, Xianhong; Xue, Xiaonan; Strickler, Howard D (2018) Generalized linear mixed model for binary outcomes when covariates are subject to measurement errors and detection limits. Stat Med 37:119-136

Showing the most recent 10 out of 1508 publications