Histopathology

Beck, Amanda P.

Abstract

- HISTOLOGY AND COMPARATIVE PATHOLOGY SHARED RESOURCE The Histology and Comparative Pathology Shared Resource of the Albert Einstein Cancer Center (AECC) provides comprehensive, expert, and cost-effective necropsy, histology and histopathology support to Center investigators and the Institute of Animal Studies/Animal Barrier. The Facility is highly utilized and provides a full range of services performed by experienced histotechnicians, including tissue fixation and processing, paraffin and frozen embedding and sectioning, standard and specialized histochemical stains, enzyme histochemistry, and immunohistochemistry/immunofluorescence. Since the last CCSG renewal, the facility also supports translational studies utilizing human tissues and has a designated cryostat for cutting fresh frozen human samples for research. The Facility routinely trains users to perform various histology techniques such as preparation and fixation of samples, paraffin and cryo-sectioning of tissues and immunohistochemistry. The Facility is also equipped with a benchtop Oxford Scientific Hematology Analyzer for complete red and white blood cell analyses, and differential parameters to support the clinical pathology needs of AECC researchers. Complete gross and histological evaluation of tissues and animal models including genetically engineered mice, is performed by the Facility's ACVP (American College of Veterinary Pathology) board-certified veterinary pathologist, Amanda Beck, DVM, DACVP. In addition to routine diagnostics, Dr. Beck develops grading systems for semi-quantitative analysis of tissues, evaluates and troubleshoots histochemical and immunohistochemical stains. Dr. Beck provides written reports that include study methods and results for manuscripts and grants, performs gross and histological photography for manuscripts, grants and presentations and advises on the development and evaluation of experimental protocols for animal studies.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA013330-48
• Application #: 9998881
• Study Section: Subcommittee I - Transistion to Independence (NCI)
• Project Start: 1997-06-01
• Project End: 2022-06-30
• Budget Start: 2020-07-01
• Budget End: 2021-06-30
• Support Year: 48
• Fiscal Year: 2020

Institution

• Name: Albert Einstein College of Medicine
• DUNS #: 081266487
• City: Bronx
• State: NY
• Country: United States
• Zip Code: 10461

Publications

Willis, Ian M; Moir, Robyn D; Hernandez, Nouria (2018) Metabolic programming a lean phenotype by deregulation of RNA polymerase III. Proc Natl Acad Sci U S A 115:12182-12187

Hayama, Ryo; Sparks, Samuel; Hecht, Lee M et al. (2018) Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex. J Biol Chem 293:4555-4563

Martynova, Elena; Bouchard, Maxime; Musil, Linda S et al. (2018) Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens. Dev Dyn 247:1186-1198

Huang, Kezhen; Mukherjee, Subhajit; DesMarais, Vera et al. (2018) Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. Pediatr Res 83:1031-1040

Bines, Jose; Tevaarwerk, Amye J (2018) Baby steps: Pregnancy outcomes after human epidermal growth factor receptor 2-targeted therapy. Cancer :

Mathew, Deepti; Wang, Yanhua; Van Arsdale, Anne et al. (2018) Expression of ?V-Tubulin in Secretory Cells of the Fallopian Tube Epithelium Marks Cellular Atypia. Int J Gynecol Cancer 28:363-370

Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394

Entenberg, David; Voiculescu, Sonia; Guo, Peng et al. (2018) A permanent window for the murine lung enables high-resolution imaging of cancer metastasis. Nat Methods 15:73-80

Iqbal, Niloy Jafar; Lu, Zhonglei; Liu, Shun Mei et al. (2018) Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity. JCI Insight 3:

Sharma, Yogeshwar; Liu, Jinghua; Kristian, Kathleen E et al. (2018) In Atp7b-/- Mice Modeling Wilson's Disease Liver Repopulation with Bone Marrowderived Myofibroblasts or Inflammatory Cells and not Hepatocytes is Deleterious. Gene Expr :