Histopathology

Beck, Amanda P.

Abstract

- HISTOLOGY AND COMPARATIVE PATHOLOGY SHARED RESOURCE The Histology and Comparative Pathology Shared Resource of the Albert Einstein Cancer Center (AECC) provides comprehensive, expert, and cost-effective necropsy, histology and histopathology support to Center investigators and the Institute of Animal Studies/Animal Barrier. The Facility is highly utilized and provides a full range of services performed by experienced histotechnicians, including tissue fixation and processing, paraffin and frozen embedding and sectioning, standard and specialized histochemical stains, enzyme histochemistry, and immunohistochemistry/immunofluorescence. Since the last CCSG renewal, the facility also supports translational studies utilizing human tissues and has a designated cryostat for cutting fresh frozen human samples for research. The Facility routinely trains users to perform various histology techniques such as preparation and fixation of samples, paraffin and cryo-sectioning of tissues and immunohistochemistry. The Facility is also equipped with a benchtop Oxford Scientific Hematology Analyzer for complete red and white blood cell analyses, and differential parameters to support the clinical pathology needs of AECC researchers. Complete gross and histological evaluation of tissues and animal models including genetically engineered mice, is performed by the Facility's ACVP (American College of Veterinary Pathology) board-certified veterinary pathologist, Amanda Beck, DVM, DACVP. In addition to routine diagnostics, Dr. Beck develops grading systems for semi-quantitative analysis of tissues, evaluates and troubleshoots histochemical and immunohistochemical stains. Dr. Beck provides written reports that include study methods and results for manuscripts and grants, performs gross and histological photography for manuscripts, grants and presentations and advises on the development and evaluation of experimental protocols for animal studies.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA013330-48
• Application #: 9998881
• Study Section: Subcommittee I - Transistion to Independence (NCI)
• Project Start: 1997-06-01
• Project End: 2022-06-30
• Budget Start: 2020-07-01
• Budget End: 2021-06-30
• Support Year: 48
• Fiscal Year: 2020

Institution

• Name: Albert Einstein College of Medicine
• DUNS #: 081266487
• City: Bronx
• State: NY
• Country: United States
• Zip Code: 10461

Publications

Mocholi, Enric; Dowling, Samuel D; Botbol, Yair et al. (2018) Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy. Cell Rep 24:1136-1150

Mao, Serena P H; Park, Minji; Cabrera, Ramon M et al. (2018) Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res 20:131

Guan, Fangxia; Tabrizian, Tahmineh; Novaj, Ardijana et al. (2018) Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis. Front Nutr 5:37

Yang, Chia-Ping Huang; Wang, Changwei; Ojima, Iwao et al. (2018) Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of ?-Tubulin and the Multidrug Resistance Associated P-Glycoprotein. J Nat Prod 81:600-606

Chennamadhavuni, Divya; Saavedra-Avila, Noemi Alejandra; Carreño, Leandro J et al. (2018) Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chem Biol 25:571-584.e8

Wang, Tao; Hosgood, H Dean; Lan, Qing et al. (2018) The Relationship Between Population Attributable Fraction and Heritability in Genetic Studies. Front Genet 9:352

Rocha, Agostinho G; Franco, Antonietta; Krezel, Andrzej M et al. (2018) MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science 360:336-341

Limi, Saima; Senecal, Adrien; Coleman, Robert et al. (2018) Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem 293:13176-13190

Cabahug-Zuckerman, Pamela; Stout Jr, Randy F; Majeska, Robert J et al. (2018) Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation. J Orthop Res 36:642-652

Vilchèze, Catherine; Copeland, Jacqueline; Keiser, Tracy L et al. (2018) Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy. MBio 9: