The mission of the Herbert Irving Comprehensive Cancer Center is to provide the organizational infrastructure and the resources to promote interdisciplinary laboratory, clinical and population based cancer research and to facilitate the application of the research to cancer prevention, diagnosis and treatment, especially for patients in the tri- state region (Norther New Jersey, South Eastern New York and Southwestern Connecticut) served by the Cancer Center. Furthermore the Cancer Center provides education and training in cancer research for scientists, clinical investigators and health professionals at all levels as well as for patients and the lay community. These objectives are facilitated by an organizational structure that has 4 major divisions: 1) Laboratory Research; 2) Clinical Research; 3) Cancer Causation, Prevention, and Control and 4) Core Facilities. Essential support is provided by the Office of Administration and a Visiting Scientific Advisory Committee. Fields of research are organized into a total of 11 Programs that facilitate research within a given discipline and foster interdisciplinary collaboration. A major function of this grant is to support a series of 14 shared core facilities that provide state-of- the-art expertise, technology and resources with considerable efficiency and cost savings. A specific emphasis of this Cancer Center, and a unifying theme that joins together this interdisciplinary research approach, is the use of concepts and methods in cellular and molecular biology to enhance our understanding of the etiology and pathophysiology of human cancer, and to develop more effective strategies for cancer prevention, diagnosis and treatment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA013696-29S2
Application #
6585457
Study Section
Subcommittee G - Education (NCI)
Program Officer
Rosenfeld, Bobby
Project Start
1976-09-01
Project End
2003-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
29
Fiscal Year
2002
Total Cost
$98,100
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Shang, Enyuan; Zhang, Yiru; Shu, Chang et al. (2018) Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems. Sci Rep 8:15383
Proto, Jonathan D; Doran, Amanda C; Subramanian, Manikandan et al. (2018) Hypercholesterolemia induces T cell expansion in humanized immune mice. J Clin Invest 128:2370-2375
Apatoff, Mary Ben L; Sengillo, Jesse D; White, Eugenia C et al. (2018) Autologous stem cell therapy for inherited and acquired retinal disease. Regen Med 13:89-96
Shen, Megan Johnson; Prigerson, Holly G; Ratshikana-Moloko, Mpho et al. (2018) Illness Understanding and End-of-Life Care Communication and Preferences for Patients With Advanced Cancer in South Africa. J Glob Oncol :1-9
Connors, Thomas J; Baird, J Scott; Yopes, Margot C et al. (2018) Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection. J Immunol 201:432-439
Billing, David; Horiguchi, Michiko; Wu-Baer, Foon et al. (2018) The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection. Mol Cell 72:127-139.e8
Wu, Hui-Chen; Do, Catherine; Andrulis, Irene L et al. (2018) Breast cancer family history and allele-specific DNA methylation in the legacy girls study. Epigenetics 13:240-250
Brescia, Paola; Schneider, Christof; Holmes, Antony B et al. (2018) MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis. Cancer Cell 34:453-465.e9
Tzoneva, Gannie; Dieck, Chelsea L; Oshima, Koichi et al. (2018) Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature 553:511-514
Sitko, Austen A; Kuwajima, Takaaki; Mason, Carol A (2018) Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway. J Comp Neurol 526:1077-1096

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