Abstract

The Center for Radiological Research offers a comprehensive irradiation service for members of the Cancer Center. This Radiation Laboratory Research Facility is a source of x-rays, gamma-rays and magnetic fields. Anything from macromolecules to small animals can be accommodate, with a large range of doses and dose-rates. The irradiation devices are used in such broad ranging studies as irradiating mice prior to injection with cells, irradiating cells to create feeder layers. creating multiple double strand breaks in the chromosomes of cells prior to radiation fusions, producing radiation transformed cell lines, as well as other applications. The Facility is made up of five irradiation devices; a Siemans X-ray Therapy Unit with operating energies up to 300 keV, an Atomic Energy of Canada Cesium Unit with dose rate of 1Gy/min, a Gamma cell-220 irradiator, which produces a dose rate of 180Gy/min, and two magnetic field exposure systems. The operators of the Facility provide users with safe and efficient operation guidance as well as consultation on dosimetry.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA013696-30S2
Application #
6665594
Study Section
Project Start
2002-07-23
Project End
2003-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
30
Fiscal Year
2002
Total Cost
$296,752
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Tzoneva, Gannie; Dieck, Chelsea L; Oshima, Koichi et al. (2018) Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature 553:511-514
Sitko, Austen A; Kuwajima, Takaaki; Mason, Carol A (2018) Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway. J Comp Neurol 526:1077-1096
Chen, Yen-Hua; Kratchmarov, Radomir; Lin, Wen-Hsuan W et al. (2018) Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell Rep 22:860-868
Wang, Gang; Biswas, Anup K; Ma, Wanchao et al. (2018) Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle. Nat Med 24:770-781
Cho, Galaxy Y; Schaefer, Kellie A; Bassuk, Alexander G et al. (2018) CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING. Retina 38:1443-1455
Zyablitskaya, Mariya; Munteanu, E Laura; Nagasaki, Takayuki et al. (2018) Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking (TXL) for Myopia. J Vis Exp :
Arnes, Luis; Liu, Zhaoqi; Wang, Jiguang et al. (2018) Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut :
Petersen-Jones, Simon M; Occelli, Laurence M; Winkler, Paige A et al. (2018) Patients and animal models of CNG?1-deficient retinitis pigmentosa support gene augmentation approach. J Clin Invest 128:190-206
Sones, Jennifer L; Merriam, Audrey A; Seffens, Angelina et al. (2018) Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia. FASEB J 32:2574-2586
Park, Karen Sophia; Xu, Christine L; Cui, Xuan et al. (2018) Reprogramming the metabolome rescues retinal degeneration. Cell Mol Life Sci 75:1559-1566

Showing the most recent 10 out of 331 publications