The long-term goals of the Cancer Epidemiology (CE) Program are to investigate environmental, lifestyleand genetic factors that lead to increased incidence, morbidity and mortality from cancer and to integratebiomarkers into these studies. To achieve this end, the following Specific Goals will be pursued: 1. Carryout molecular epidemiology studies that broadly include the integration of data collected frombiospecimens with epidemiologic data to understand cancer risk. These studies will take advantageof almost 20 cohorts actively being studied, many with biospecimens, and the long history of research inthe CE Program using biomarkers. 2. Investigate how exposures in key susceptible time periods altercancer susceptibility. Lifecourse epidemiology and timing of events will be used to capture risk factordata from pre and postnatal periods. 3. Conduct epidemiologic studies around the globe. Longitudinalresearch is being carried out in Latin America, Asia, Eastern and Western Europe and the Middle East.The CE Program consists of 15 members (all full members) from 3 departments within the School of PublicHealth and 2 departments within the College of Physicians & Surgeons at Columbia University. TheProgram is supported by several large Federally-funded collaborative grants including the Breast CancerFamily Registry, the NIEHS Center for Environmental Health in Northern Manhattan and a Superfund BasicResearch Program.For the last budget year of the grant (July 1, 2006 - June 30, 2007), the CE Program successfully obtaineda total of $6.8M (direct costs) in cancer-relevant grant support, including $2.3M (direct costs) in NCIfunding, $4.1 M (direct costs) in other cancer-related peer-reviewed funding, and $0.4M (direct costs) incancer-related non-peer-reviewed funding. The total number of publications since the previous submission(i.e., 2003-present) was 181 of which 42% were intra-programmatic and 36% inter-programmatic.
| DiCarlo, James E; Mahajan, Vinit B; Tsang, Stephen H (2018) Gene therapy and genome surgery in the retina. J Clin Invest 128:2177-2188 |
| Wert, Katherine J; Velez, Gabriel; Cross, Madeline R et al. (2018) Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface. Free Radic Biol Med 124:408-419 |
| Lee, Andreia; CingÖz, Oya; Sabo, Yosef et al. (2018) Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. Virology 516:165-175 |
| Schrank, Benjamin R; Aparicio, Tomas; Li, Yinyin et al. (2018) Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559:61-66 |
| Proto, Jonathan D; Doran, Amanda C; Gusarova, Galina et al. (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49:666-677.e6 |
| Hernandez, Celine; Huebener, Peter; Pradere, Jean-Philippe et al. (2018) HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest 128:2436-2451 |
| Lee, Younghyun; Pujol Canadell, Monica; Shuryak, Igor et al. (2018) Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model. Sci Rep 8:13557 |
| Kraakman, Michael J; Liu, Qiongming; Postigo-Fernandez, Jorge et al. (2018) PPAR? deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects. J Clin Invest 128:2600-2612 |
| Cui, Xuan; Jauregui, Ruben; Park, Karen Sophia et al. (2018) Multimodal characterization of a novel mutation causing vitamin B6-responsive gyrate atrophy. Ophthalmic Genet 39:512-516 |
| Evans, Lucy P; Newell, Elizabeth A; Mahajan, MaryAnn et al. (2018) Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice. Ann Clin Transl Neurol 5:240-251 |
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