The long-term goal of the Prevention, Control, and Disparities (PCD) Program is to study how the research findings of basic, epidemiologic, and clinical research have been or should be disseminated and applied in real life. To achieve this end, the following Specific Goals will be pursued: 1) Primary prevention and early detection - We focus on the reduction of the use and ill effects of tobacco as well as other risk factors such as obesity, sedentary lifestyle, and diet and the study of screening for colorectal, cervical and other cancers; and 2) Health outcomes, quality of care and survivorship - We study patterns and quality of cancer care, and the impact of various factors on outcomes, including mortality and long-term side effects, and also study management and outcomes in cancer survivors. Thus, the Program's strengths in the study of primary prevention, as well as racial/ethnic disparities, survivorship and health outcomes research, have become significant and interactive with other programs in the Cancer Center, including the Breast Cancer Program, Cancer Epidemiology Program, Prostate Cancer Program, and others. The Program is also highly active within the local catchment area in research as well as providing service, and is developing a global research portfolio. The PCD Program consists of 34 members (24 full) from 16 departments among six schools within Columbia University. The Program is supported by large program project grants, including a Breast Cancer Center of Excellence grant to study racial disparities in breast cancer treatment, and multiple ROI s and other research grants. For the last full budget year of the grant (July 1, 2012 - June 30, 2013), the PCD Program received a total of $9.4M in cancer-relevant grant support, including $1.38M in NCI funding, $7.47M in other cancer-related peer-reviewed funding, and $0.55M in cancer-related non-peer-reviewed funding. The total number of publications since the previous submission (i.e., 2008-present) was 576 of which 16% were intra-programmatic and 40% inter-programmatic, and 10% were in high impact journals (Impact Factor >10).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA013696-40
Application #
8753116
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-07-04
Project End
2019-06-30
Budget Start
2014-07-17
Budget End
2015-06-30
Support Year
40
Fiscal Year
2014
Total Cost
$33,319
Indirect Cost
$12,495
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Sitko, Austen A; Kuwajima, Takaaki; Mason, Carol A (2018) Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway. J Comp Neurol 526:1077-1096
Tzoneva, Gannie; Dieck, Chelsea L; Oshima, Koichi et al. (2018) Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature 553:511-514
Wang, Gang; Biswas, Anup K; Ma, Wanchao et al. (2018) Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle. Nat Med 24:770-781
Chen, Yen-Hua; Kratchmarov, Radomir; Lin, Wen-Hsuan W et al. (2018) Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell Rep 22:860-868
Cho, Galaxy Y; Schaefer, Kellie A; Bassuk, Alexander G et al. (2018) CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING. Retina 38:1443-1455
Zyablitskaya, Mariya; Munteanu, E Laura; Nagasaki, Takayuki et al. (2018) Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking (TXL) for Myopia. J Vis Exp :
Arnes, Luis; Liu, Zhaoqi; Wang, Jiguang et al. (2018) Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut :
Petersen-Jones, Simon M; Occelli, Laurence M; Winkler, Paige A et al. (2018) Patients and animal models of CNG?1-deficient retinitis pigmentosa support gene augmentation approach. J Clin Invest 128:190-206
Sones, Jennifer L; Merriam, Audrey A; Seffens, Angelina et al. (2018) Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia. FASEB J 32:2574-2586
Park, Karen Sophia; Xu, Christine L; Cui, Xuan et al. (2018) Reprogramming the metabolome rescues retinal degeneration. Cell Mol Life Sci 75:1559-1566

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