The Database Shared Resource (DBSR) is a new core within the Herbert Irving Comprehensive Cancer Center (HICCC), whose central function is to provide oversight and infrastructure for the development and maintenance of cancer-related clinical databases and link them to existing biobanks. Our overall objective is to stimulate multi-disciplinary clinical and translational research utilizing these databases and biobanks. Services provided include: Coordinating clinical database-related services with other shared resources Providing IT support for data storage, clinical data extraction, and quality measures Providing support and resources for questionnaire development for biobanks Disseminating information about the clinical databases and biobanks to the research community Reviewing requests to access the clinical databases and biobanks and tracking utilization There are currently sixteen cancer-related clinical databases and biobanks at Columbia University Medical Center (CUMC). Our goal is to standardize and streamline the management of these clinical databases and biobanks, ensure that they meet IRB, HIPAA, and CUMC IT Security requirements, and develop them into a valuable resource for the HICCC research community. This entails the coordination of efforts with other shared resources to facilitate recruitment and consenting of database participants, administration of epidemiologic questionnaires, collection of biospecimens, and extraction of clinical data from the cancer registry and electronic health record (EHR). Our future plans include integrating these cancer-related clinical database and biobanking efforts with the Personalized Medicine Research Initiative at CUMC and to develop more efficient ways of extracting clinical data from the EHR, including the use of patient portals. Our goal is to merge all of the disease-specific databases into one HICCC clinical database, which will enroll all newly diagnosed cancer patients and healthy at-risk individuals seen at our Cancer Center and link their epidemiologic questionnaire data and clinical information with tumor tissue, blood, DNA, and other biospecimens. The proposed total operating budget for the DBSR is $153,887, ofwhich we are requesting $35,223 from the CCSG.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA013696-40
Application #
8753134
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-07-04
Project End
2019-06-30
Budget Start
2014-07-17
Budget End
2015-06-30
Support Year
40
Fiscal Year
2014
Total Cost
$50,233
Indirect Cost
$18,837
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Ghorpade, Devram S; Ozcan, Lale; Zheng, Ze et al. (2018) Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature 555:673-677
Jauregui, Ruben; Thomas, Amanda L; Liechty, Benjamin et al. (2018) SCAPER-associated nonsyndromic autosomal recessive retinitis pigmentosa. Am J Med Genet A :
Jauregui, Ruben; Park, Karen Sophia; Duong, Jimmy K et al. (2018) Quantitative Comparison of Near-infrared Versus Short-wave Autofluorescence Imaging in Monitoring Progression of Retinitis Pigmentosa. Am J Ophthalmol 194:120-125
Bianchetti, E; Bates, S J; Carroll, S L et al. (2018) Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors. Sci Rep 8:17390
Shang, Enyuan; Zhang, Yiru; Shu, Chang et al. (2018) Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems. Sci Rep 8:15383
Proto, Jonathan D; Doran, Amanda C; Subramanian, Manikandan et al. (2018) Hypercholesterolemia induces T cell expansion in humanized immune mice. J Clin Invest 128:2370-2375
Apatoff, Mary Ben L; Sengillo, Jesse D; White, Eugenia C et al. (2018) Autologous stem cell therapy for inherited and acquired retinal disease. Regen Med 13:89-96
Shen, Megan Johnson; Prigerson, Holly G; Ratshikana-Moloko, Mpho et al. (2018) Illness Understanding and End-of-Life Care Communication and Preferences for Patients With Advanced Cancer in South Africa. J Glob Oncol :1-9
Connors, Thomas J; Baird, J Scott; Yopes, Margot C et al. (2018) Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection. J Immunol 201:432-439
Billing, David; Horiguchi, Michiko; Wu-Baer, Foon et al. (2018) The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection. Mol Cell 72:127-139.e8

Showing the most recent 10 out of 331 publications