The Herbert Irving Comprehensive Cancer Center (HICCC) was designated as a National Cancer Institute (NCI) Cancer Center in 1972 and gained comprehensive status in 1979. The HICCC is the critical driver of cancer scientific research, clinical trials, innovative patient care, cancer education and training and community outreach at Columbia University?s Irving Medical Center (CUIMC) and NewYork-Presbyterian Hospital (NYPH). During the current project period (2014-present), CUIMC and NYPH committed $415M for the following: (1) new research initiatives in basic, translational, clinical and population sciences with >50 strategic faculty recruitments; (2) new and expanded facilities for laboratory research, dry bench research and clinical activities; (3) major faculty recruitments; and, (4) support of the HICCC?s administrative core. A major aspect was the recruitment of Anil K. Rustgi, MD as the HICCC Director in late 2018. Rustgi has the unequivocal authority over cancer research space and cancer care facilities and accompanying substantial resources through the transformative Irving Family Trust Gift, further reinforced through his dual roles as Associate Dean of Oncology (CUIMC) and Chief of Cancer Services (NYPH). Over this project period, there was a greater focus upon transdisciplinary cross-cutting scientific themes that catalyzed the restructuring of the scientific research programs encompassing 175 members from 34 Departments and six Schools: Cancer Genomics and Epigenomics; Tumor Biology and Microenvironment; Precision Oncology and Systems Biology; and, Cancer Population Science. Importantly, Rustgi created units dedicated to Community Outreach and Engagement (COE) and Cancer Research Career Enhancement (CRCE) and enhanced the 12 Shared Resources. The Research Programs engendered impactful science with 3,399 publications of which 626 were intra-programmatic and 456 were inter-programmatic. Total NCI funding is $26M and cancer-relevant funding is $92M. The HICCC is requesting CCSG support of $4.1M per year (total DC) for the next project period.

Public Health Relevance

OVERALL: NARRATIVE Cancer is a deadly disease for which there is no panacea but requires a multi-pronged approach to improve the outcomes of our patients. To that end, the Herbert Irving Comprehensive Cancer Center at Columbia University Irving Medical Center/New York Presbyterian Hospital is dedicated to the vision and mission of reducing the cancer burden in our catchment area. The HICCC spans basic, translational, clinical and population research that is supported by shared resources, community outreach and engagement, training and education, and strategic investments, all converging on cancer screening, surveillance, early detection, prognosis, therapy, survivorship and palliation.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Belin, Precilla L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Internal Medicine/Medicine
Schools of Medicine
New York
United States
Zip Code
Cui, Xuan; Jauregui, Ruben; Park, Karen Sophia et al. (2018) Multimodal characterization of a novel mutation causing vitamin B6-responsive gyrate atrophy. Ophthalmic Genet 39:512-516
Evans, Lucy P; Newell, Elizabeth A; Mahajan, MaryAnn et al. (2018) Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice. Ann Clin Transl Neurol 5:240-251
Dieck, Chelsea L; Tzoneva, Gannie; Forouhar, Farhad et al. (2018) Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 34:136-147.e6
Nathan, J; Ruscitto, A; Pylawka, S et al. (2018) Fibrocartilage Stem Cells Engraft and Self-Organize into Vascularized Bone. J Dent Res 97:329-337
Sengillo, Jesse D; Lee, Winston; Bakhoum, Mathieu F et al. (2018) CHOROIDEREMIA ASSOCIATED WITH A NOVEL SYNONYMOUS MUTATION IN GENE ENCODING REP-1. Retin Cases Brief Rep 12 Suppl 1:S67-S71
Kratchmarov, Radomir; Viragova, Sara; Kim, Min Jung et al. (2018) Metabolic control of cell fate bifurcations in a hematopoietic progenitor population. Immunol Cell Biol 96:863-871
Xu, Christine L; Park, Karen Sophia; Tsang, Stephen H (2018) CRISPR/Cas9 genome surgery for retinal diseases. Drug Discov Today Technol 28:23-32
Gartrell, Robyn D; Marks, Douglas K; Hart, Thomas D et al. (2018) Quantitative Analysis of Immune Infiltrates in Primary Melanoma. Cancer Immunol Res 6:481-493
Moayedi, Yalda; Duenas-Bianchi, Lucia F; Lumpkin, Ellen A (2018) Somatosensory innervation of the oral mucosa of adult and aging mice. Sci Rep 8:9975
Sengillo, Jesse D; Lee, Winston; Bilancia, Colleen G et al. (2018) Phenotypic expansion and progression of SPATA7-associated retinitis pigmentosa. Doc Ophthalmol 136:125-133

Showing the most recent 10 out of 331 publications