Abstract

This is a request for five years of core support beginning September 1, 1980 following the termination of NCI Grant CA 14051. The Cancer Center Support (Core) Grant is requested to provide funds for shared facilities and services, including research salaries for professional staff (the faculty members who as a group operate the program of the Center), centralized services, shared equipment, developmental funds, and administration. Research will be carried out in three main areas of Cancer Biology: 1) Cancer Virology - this group, led by five faculty members, concentrates primarily on the identification of cancer-inducing genes and their products. 2) Cancer Immunology - this program, led by three faculty members, places its major effort in the study of the mechanism by which killer T lymphocytes destroy foreign or cancer cells in vivo and in vitro. 3) Cancer Cell Biology, with four faculty members, explores the biochemical changes that occur on the cell surface and in the cytoskeleton as a result of mailignant transformation. This Core Grant will aid further development of the Center by providing partial support for initial research costs of two new faculty members: a replacement in the Immunology Group and an addition to the Cell Biology Group. Development funds are also requested for the support of exploratory projects in the initial phase, prior to application for peer-reviewed funding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-16
Application #
3101367
Study Section
Cancer Center Support Grant Review Committee (CCS)
Project Start
1975-09-01
Project End
1990-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
16
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Wong, Madeline Y; Chen, Kenny; Antonopoulos, Aristotelis et al. (2018) XBP1s activation can globally remodel N-glycan structure distribution patterns. Proc Natl Acad Sci U S A 115:E10089-E10098
Viswanathan, Srinivas R; Nogueira, Marina F; Buss, Colin G et al. (2018) Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet 50:937-943
Goods, Brittany A; Vahey, Jacqueline M; Steinschneider, Arthur F et al. (2018) Blood handling and leukocyte isolation methods impact the global transcriptome of immune cells. BMC Immunol 19:30
Kaczmarek, James C; Kauffman, Kevin J; Fenton, Owen S et al. (2018) Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells. Nano Lett 18:6449-6454
Perez, Dahlia E; Henle, Andrea M; Amsterdam, Adam et al. (2018) Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology. Pigment Cell Melanoma Res 31:604-613
Wu, Connie; Li, Jiahe; Wang, Wade et al. (2018) Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing. ACS Nano 12:6504-6514
Ordovas-Montanes, Jose; Dwyer, Daniel F; Nyquist, Sarah K et al. (2018) Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature 560:649-654
Lam, Fred C; Morton, Stephen W; Wyckoff, Jeffrey et al. (2018) Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nat Commun 9:1991
Chiu, Anthony C; Suzuki, Hiroshi I; Wu, Xuebing et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Mol Cell 69:648-663.e7
Weidberg, Hilla; Amon, Angelika (2018) MitoCPR-A surveillance pathway that protects mitochondria in response to protein import stress. Science 360:

Showing the most recent 10 out of 904 publications