Abstract

This is a request for five years of core support beginning September 1, 1980 following the termination of NCI Grant CA 14051. The Cancer Center Support (Core) Grant is requested to provide funds for shared facilities and services, including research salaries for professional staff (the faculty members who as a group operate the program of the Center), centralized services, shared equipment, developmental funds, and administration. Research will be carried out in three main areas of Cancer Biology: 1) Cancer Virology - this group, led by five faculty members, concentrates primarily on the identification of cancer-inducing genes and their products. 2) Cancer Immunology - this program, led by three faculty members, places its major effort in the study of the mechanism by which killer T lymphocytes destroy foreign or cancer cells in vivo and in vitro. 3) Cancer Cell Biology, with four faculty members, explores the biochemical changes that occur on the cell surface and in the cytoskeleton as a result of mailignant transformation. This Core Grant will aid further development of the Center by providing partial support for initial research costs of two new faculty members: a replacement in the Immunology Group and an addition to the Cell Biology Group. Development funds are also requested for the support of exploratory projects in the initial phase, prior to application for peer-reviewed funding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-16
Application #
3101367
Study Section
Cancer Center Support Grant Review Committee (CCS)
Project Start
1975-09-01
Project End
1990-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
16
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Tam, Brooke E; Hao, Yining; Sikes, Hadley D (2018) An examination of critical parameters in hybridization-based epigenotyping using magnetic microparticles. Biotechnol Prog 34:1589-1595
Ramadi, Khalil B; Dagdeviren, Canan; Spencer, Kevin C et al. (2018) Focal, remote-controlled, chronic chemical modulation of brain microstructures. Proc Natl Acad Sci U S A 115:7254-7259
Knouse, Kristin A; Lopez, Kristina E; Bachofner, Marc et al. (2018) Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture. Cell 175:200-211.e13
Sabari, Benjamin R; Dall'Agnese, Alessandra; Boija, Ann et al. (2018) Coactivator condensation at super-enhancers links phase separation and gene control. Science 361:
Clancy-Thompson, Eleanor; Devlin, Christine A; Tyler, Paul M et al. (2018) Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses. Cancer Immunol Res 6:1524-1536
Fiedler, Eleanor R C; Bhutkar, Arjun; Lawler, Emily et al. (2018) In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1 + BCP-ALL. Blood Adv 2:1229-1242
Sullivan, Lucas B; Luengo, Alba; Danai, Laura V et al. (2018) Aspartate is an endogenous metabolic limitation for tumour growth. Nat Cell Biol 20:782-788
Miller, Eric A; Baniya, Subha; Osorio, Daniel et al. (2018) Paper-based diagnostics in the antigen-depletion regime: High-density immobilization of rcSso7d-cellulose-binding domain fusion proteins for efficient target capture. Biosens Bioelectron 102:456-463
Lannagan, Tamsin R M; Lee, Young K; Wang, Tongtong et al. (2018) Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. Gut :
Filbin, Mariella G; Tirosh, Itay; Hovestadt, Volker et al. (2018) Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science 360:331-335

Showing the most recent 10 out of 904 publications