The Center for Cancer Research is dedicated to investigations of the basic aspects of the development of cancer in mammals. These investigations are multidiscipline and have a synergic cohesion by inclusion into one physical structure. Research on the cellular, molecular and genetic basis of cancer is organized into three program areas: Cancer Immunology, Cancer Cell Biology, and Tumor Virology and Genetics. Many of the studies in the Cancer Immunology Program are concerned with genetic mechanisms underlying the diversity of immune response of both T and B lymphocytes. In addition, cellular processes controlling immunological reactions are being investigated. The Cancer Cell Biology Program has research efforts in the general area of the synthesis and modification of proteins on the surface of cells and the relationship between extracellular structure, cell morphology, and cell growth. The Tumor Virology and Genetics Program has a major emphasis on the activity of oncogenes in the development of cancer. This includes investigations of the regulations of gene expression by oncogenes, activation of oncogenes and development of methodologies for genetic analysis of human diseases.
| Huang, Hsin-Ho; Qian, Yili; Del Vecchio, Domitilla (2018) A quasi-integral controller for adaptation of genetic modules to variable ribosome demand. Nat Commun 9:5415 |
| Guimarães, Pedro P G; Gaglione, Stephanie; Sewastianik, Tomasz et al. (2018) Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano 12:912-931 |
| Nath, Samir R; Yu, Zhigang; Gipson, Theresa A et al. (2018) Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. J Clin Invest 128:3630-3641 |
| Moynihan, Kelly D; Holden, Rebecca L; Mehta, Naveen K et al. (2018) Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability. Cancer Immunol Res 6:1025-1038 |
| Rothenberg, Daniel A; Taliaferro, J Matthew; Huber, Sabrina M et al. (2018) A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9:367-381 |
| Kimmerling, Robert J; Prakadan, Sanjay M; Gupta, Alejandro J et al. (2018) Linking single-cell measurements of mass, growth rate, and gene expression. Genome Biol 19:207 |
| Tang, Li; Zheng, Yiran; Melo, Mariane Bandeira et al. (2018) Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery. Nat Biotechnol 36:707-716 |
| Holec, Patrick V; Berleant, Joseph; Bathe, Mark et al. (2018) A Bayesian framework for high-throughput T cell receptor pairing. Bioinformatics : |
| Wong, Madeline Y; Doan, Ngoc Duc; DiChiara, Andrew S et al. (2018) A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production. Biochemistry 57:2814-2827 |
| Danai, Laura V; Babic, Ana; Rosenthal, Michael H et al. (2018) Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature 558:600-604 |
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