Administrative: The Cancer Center Support Grant is administered by the Koch Institute for Integrative Cancer Research at MIT under the direction of Ms. Cynthia Quense, the Assistant Director for Administration. The Koch Institute has a centralized administrative system to support the Members within the Koch Institute building. This structure allows for specialization within areas while also providing administrative staff that are very familiar with the individualized needs of Members and their respective laboratories. The central administration team (known as the Headquarters Office (HQ)) provides support to the Koch Institute in the following key areas: Finance, pre and post award of research and discretionary funds; Human Resources; Operations (Facilities & Building Maintenance); Program and Grant Administration; Reception/Office Management, and; Koch Institute Events including Symposium, Retreat and Special Seminars. Coordination and oversight is also provided to research administration areas including Environment, Health, and Safety (EHS), financial oversight of Core Facilities and Faculty Administrative Assistants. In addition, the HQ team provides CCSG-specific administrative support to the Members outside of the building in the areas of: Core Facilities operations and billing, Membership, Program support, Pilot Projects, other internal funding mechanisms, funding announcements, cancer-related fellowships; and, full administrative support for Center grants including CCNE, PSOC, ICBP and the Ludwig Center. Ms. Quense was hired in January 2007. She holds an MPA from Harvard and has an extensive background in non-profit and academic financial administration and administrative management. Ms. Quense reports directly to Dr. Jacks, Director of the Koch Institute, and is part of the CCSG Senior Leadership and the Executive Committee. Ms. Quense also interfaces with MIT administrative officials to ensure a cohesive relationship between the Koch Institute and the Institute. She also serves as liaison with the Howard Hughes Medical Institute. There are 20 FTEs on the HQ team. This has grown from 16 in the last renewal linked to the expansion to the Koch Institute building. Of the 20 HQ staff, support for 4 FTEs is requested from the CCSG Administrative budget. The remaining staff are covered by Institutional or other research funds. Senior Leadership: The Senior Leadership of the Koch Institute consists of the Director, Dr. Tyler Jacks, the two Associate Directors, Drs. Jacqueline Lees and K. Dane Wittrup, and the Assistant Director for Administration, Ms. Cynthia Quense. The Senior Leadership meets regularly with the other CCSG Program leaders (Drs. Amon, Bhatia, Hynes, Langer, Sharp, and Yaffe ? who is also the Director of the Koch Institute Clinical Investigator Program) as the Koch Institute Executive Committee (EC) to discuss planning issues including Membership, faculty and staff hiring, junior faculty mentoring, Core Facilities, space issues, policies, and use of Developmental Funds. All costs of Senior Leadership are covered through Institutional support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-45
Application #
9149826
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Shafik, Hasnaa
Project Start
Project End
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
45
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
Clancy-Thompson, Eleanor; Devlin, Christine A; Tyler, Paul M et al. (2018) Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses. Cancer Immunol Res 6:1524-1536
Fiedler, Eleanor R C; Bhutkar, Arjun; Lawler, Emily et al. (2018) In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1 + BCP-ALL. Blood Adv 2:1229-1242
Sullivan, Lucas B; Luengo, Alba; Danai, Laura V et al. (2018) Aspartate is an endogenous metabolic limitation for tumour growth. Nat Cell Biol 20:782-788
Miller, Eric A; Baniya, Subha; Osorio, Daniel et al. (2018) Paper-based diagnostics in the antigen-depletion regime: High-density immobilization of rcSso7d-cellulose-binding domain fusion proteins for efficient target capture. Biosens Bioelectron 102:456-463
Lannagan, Tamsin R M; Lee, Young K; Wang, Tongtong et al. (2018) Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. Gut :
Filbin, Mariella G; Tirosh, Itay; Hovestadt, Volker et al. (2018) Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science 360:331-335
Roper, Jatin; Tammela, Tuomas; Akkad, Adam et al. (2018) Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Nat Protoc 13:217-234
Suzuki, Hiroshi I; Spengler, Ryan M; Grigelioniene, Giedre et al. (2018) Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nat Genet 50:657-661
McKenney, Anna Sophia; Lau, Allison N; Somasundara, Amritha Varshini Hanasoge et al. (2018) JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. J Clin Invest 128:789-804
Richardson, Christopher E R; Cunden, Lisa S; Butty, Vincent L et al. (2018) A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency. J Am Chem Soc 140:2413-2416

Showing the most recent 10 out of 904 publications