The USC/Norris Comprehensive Cancer Center at the University of Southern California was founded in 1971 and has been continuously supported by a Cancer Center Core Support Grant since 1973. It has developed into a major regional and national resource for cancer research, treatment, prevention and education. Center facilities have been built and developed with support from the NCI, the University, and the Kenneth Norris Jr. Cancer Hospital which is an integral part of the Cancer Center. The Center is undergoing a major expansion by the addition of the Norman Topping Tower (110,000 nsf) attached to the existing headquarters building. The Center's research programs are organized into five discipline-based and four disease-based programs. The discipline-based programs are headed by senior investigators in the fields of gene regulation, cell biology, developmental therapeutics and clinical trials, cancer epidemiology and cancer control research. The disease-based programs which provide focus to our multidisciplinary research efforts are in genitourinary, gastrointestinal, breast cancer and hematologic malignancy/retroviral diseases. This application is for: 1) partial salary support for the Center's senior leadership who are responsible for planning and overseeing our research efforts; 2) support for planning and evaluation to keep the Center at the forefront of cancer research; 3) support for the administrative intrastructure of the Center; 4) partial support for the Center's 13 shared resources which facilitate the conduct of our peer-reviewed research; 5) support for developmental funds to help us recruit new investigators in areas we have targeted for expansion and to provide support for pilot projects, specifically designed to stimulate translational research. Continued funding from the Cancer Center Core Support Program will allow us to build on our strengths in molecular genetics, cell biology, cancer treatment (including gene therapy), cancer epidemiology and cancer control and to translate our underlying expertise into strong, peer-reviewed funded research programs focused on cancers of major consequence in this country.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA014089-24S1
Application #
2849479
Study Section
Special Emphasis Panel (ZCA1-SRRB-3 (J1))
Program Officer
Silkensen, Shannon M
Project Start
1980-04-01
Project End
2000-11-30
Budget Start
1999-04-01
Budget End
1999-11-30
Support Year
24
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Lang, Julie E; Brownson, Kirstyn E (2018) ASO Author Reflections: The Whole Transcriptome Landscape of Circulating Tumor Cells in Nonmetastatic Breast Cancer. Ann Surg Oncol :
Poulard, Coralie; Baulu, Estelle; Lee, Brian H et al. (2018) Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death. Cell Death Dis 9:1038
Guo, Yu; Perez, Andrew A; Hazelett, Dennis J et al. (2018) CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops. Genome Biol 19:160
Milam, Joel; Slaughter, Rhona; Tobin, Jessica L et al. (2018) Childhood Cancer Survivorship and Substance Use Behaviors: A Matched Case-Control Study Among Hispanic Adolescents and Young Adults. J Adolesc Health 63:115-117
Singh, Hardeep P; Wang, Sijia; Stachelek, Kevin et al. (2018) Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. Proc Natl Acad Sci U S A 115:E9391-E9400
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu et al. (2018) Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer. Pharmacogenomics J 18:623-632
Rodrigues, Luana L S; Morgado, Mariza G; Sahasrabuddhe, Vikrant V et al. (2018) Cervico-vaginal self-collection in HIV-infected and uninfected women from Tapajós region, Amazon, Brazil: High acceptability, hrHPV diversity and risk factors. Gynecol Oncol 151:102-110
Tsai, Yuan-Li; Ha, Dat P; Zhao, He et al. (2018) Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-? signaling. Proc Natl Acad Sci U S A 115:E4245-E4254
Ricker, Charité N; Koff, Rachel B; Qu, Chenxu et al. (2018) Patient communication of cancer genetic test results in a diverse population. Transl Behav Med 8:85-94
Valentin-Torres, Alice; Savarin, Carine; Barnett, Joslyn et al. (2018) Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation. J Neuroinflammation 15:121

Showing the most recent 10 out of 842 publications