Abstract

The Program Leaders of the USC Norris Comprehensive Cancer Center (NCCC) promote both intra and inter-programmatic transdisciplinary research through careful selection of program members and recruitment of new faculty, coordination of interactions between program members and with other NCCC members, as well as facilitation and leadership of transdisciplinary and multi-project research applications, seminars, mini-symposia, program retreats and program meetings. This transdisciplinary emphasis is reinforced by having two leaders from different disciplines for most programs. For those programs with two leaders (Epigenetics and Regulation, Tumor Microenvironment, Cancer Epidemiology, Cancer Control Research, Developmental Therapeutics, Genitourinary Cancers, Gastrointestinal Cancers, Leukemia and Lymphoma and Women's Cancers) we are requesting support for 7.5% effort for each leader and for one program (Molecular Genetics) with one leader we are asking support for 10% effort.

Public Health Relevance

The Program Leaders facilitate scientific discoveries and coordinate activities to foster transdisciplinary research for the development of more effective prevention, diagnosis and treatment of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014089-37
Application #
8555585
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-12-01
Project End
2015-11-30
Budget Start
2012-02-10
Budget End
2012-11-30
Support Year
37
Fiscal Year
2012
Total Cost
$412,880
Indirect Cost
$149,318

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Liu, Minmin; Zhang, Lian; Li, Hongtao et al. (2018) Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI-110) in Hepatocellular Carcinoma. Hepatology 68:1412-1428
Miller, Kimberly A; Ramirez, Cynthia N; Wojcik, Katherine Y et al. (2018) Prevalence and correlates of health information-seeking among Hispanic and non-Hispanic childhood cancer survivors. Support Care Cancer 26:1305-1313
Belic, Jelena; Graf, Ricarda; Bauernhofer, Thomas et al. (2018) Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide. Int J Cancer 143:1236-1248
Tobin, Jessica; Allem, Jon-Patrick; Slaughter, Rhona et al. (2018) Posttraumatic growth among childhood cancer survivors: Associations with ethnicity, acculturation, and religious service attendance. J Psychosoc Oncol 36:175-188
Schaal, Justin B; Maretzky, Thorsten; Tran, Dat Q et al. (2018) Macrocyclic ?-defensins suppress tumor necrosis factor-? (TNF-?) shedding by inhibition of TNF-?-converting enzyme. J Biol Chem 293:2725-2734
Iriondo, Oihana; Liu, Yarong; Lee, Grace et al. (2018) TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun 9:1994
Robison, Nathan J; Yeo, Kee Kiat; Berliner, Adrian P et al. (2018) Phase I trial of dasatinib, lenalidomide, and temozolomide in children with relapsed or refractory central nervous system tumors. J Neurooncol 138:199-207
Naseem, Madiha; Barzi, Afsaneh; Brezden-Masley, Christine et al. (2018) Outlooks on Epstein-Barr virus associated gastric cancer. Cancer Treat Rev 66:15-22
Sebio, A; Stintzing, S; Heinemann, V et al. (2018) A genetic variant in Rassf1a predicts outcome in mCRC patients treated with cetuximab plus chemotherapy: results from FIRE-3 and JACCRO 05 and 06 trials. Pharmacogenomics J 18:43-48
Peres, Lauren C; Risch, Harvey; Terry, Kathryn L et al. (2018) Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. Int J Epidemiol 47:460-472

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