The Tumor Microenvironment Program at USC Norris was created in 2003. The concept behind this Program is that the fundamental investigation of the mechanisms that control the interaction between malignant cells and their nontransformed microenvironment should lead to the identification of novel targets for therapeutic intervention and better prognosticators. The overarching goal is to make innovative basic discoveries on the role of the tumor microenvironment (TME), and by interacting with other Programs of USC Norris, develop these discoveries into investigator-driven clinical trials. The Program has three scientific objectives: 1) to investigate the fundamental mechanisms of communication between cancer cells and their microenvironment; 2) to understand the contribution of viral-induced lymphangiogenesis/angiogenesis to Kaposi sarcoma; and 3) to understand the mechanisms of immune escape and develop new approaches to cancer immunotherapy. The Program Co-Leaders Yves DeClerck and Martin Kast have complementary recognized expertise in the tumor microenvironment and in immunotherapy, respectively. The Program brings together 28 members from 16 departments in four schools at USC with expertise and research interests in inflammation, tumor-stroma interaction, metastasis, angiogenesis, Kaposi sarcoma-associated Herpes Virus (KSHV), human papilloma virus (HPV)-mediated oncogenesis, and immunotherapy. The Program has obtained new funding in the tumor microenvironment (one U54, three R01s, one DoD) and in viral-mediated angiogenesis/lymphangiogenesis (one P01 and one R21). A unique aspect of this basic science program has been its commitment to translation. Over the last five years, the Program has been the hub where fundamental observations made by its members have led to nine clinical studies/trials. Research conducted by members of the Program has a unique impact on specific populations of the LA County catchment area, particularly children (neuroblastoma and childhood ALL), women of low economic status (HPV-induced cervical cancer), and HIV-infected patients (Kaposi sarcoma). During the current project period, Program members have published 319 papers, of which 40% are inter-programmatic, 17% are intra-programmatic, and 28% inter-institutional. Program members have $11M (direct costs) in peer-review funding, with 40% from NCI and 27% from other NIH sources, and 5% from other peer-reviewed sources.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014089-45
Application #
9838178
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
45
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Vannini, Ivan; Fanini, Francesca; Fabbri, Muller (2018) Emerging roles of microRNAs in cancer. Curr Opin Genet Dev 48:128-133
Veyseh, Maedah; Ricker, Charite; Espenschied, Carin et al. (2018) Secondary Germline Finding in Liquid Biopsy of a Deceased Patient; Case Report and Review of the Literature. Front Oncol 8:259
Bluthenthal, Ricky N; Chu, Daniel; Wenger, Lynn D et al. (2018) Differences in time to injection onset by drug in California: Implications for the emerging heroin epidemic. Drug Alcohol Depend 185:253-259
Sunakawa, Yu; Yang, Dongyun; Cao, Shu et al. (2018) Immune-related Genes to Dominate Neutrophil-lymphocyte Ratio (NLR) Associated With Survival of Cetuximab Treatment in Metastatic Colorectal Cancer. Clin Colorectal Cancer 17:e741-e749
Skeate, Joseph G; Da Silva, Diane M; Chavez-Juan, Elena et al. (2018) Nano-Pulse Stimulation induces immunogenic cell death in human papillomavirus-transformed tumors and initiates an adaptive immune response. PLoS One 13:e0191311
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Kiran, Sayee; Jeong, Young Ju; Nelson, Maria E et al. (2018) Are we overtreating intraductal papillomas? J Surg Res 231:387-394
Basso, Virginia; Garcia, Angie; Tran, Dat Q et al. (2018) Fungicidal Potency and Mechanisms of ?-Defensins against Multidrug-Resistant Candida Species. Antimicrob Agents Chemother 62:
Neumeyer, Sonja; Banbury, Barbara L; Arndt, Volker et al. (2018) Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. Br J Cancer 118:1639-1647

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