The DCI-Designated Program in Cancer Genetics and Genomics (CGG) program was re-organized in 2012 by merging two pre-existing programs and recruiting new faculty around the central themes of cancer genetics, epigenetics, gene expression, and genomics. The goals of the Program are to coordinate the Duke Cancer Institute research activities related to the aforementioned themes and to inform the application of 'omics' technologies that assess alterations in cancer genomes, epigenomes and transcriptomes. This interactive and integrated program is organized into three Focus Groups: (1) Epigenetics and Epigenomics, (2) DNA Replication, Recombination and Repair, and (3) Gene Expression (which includes viral oncology). The Program includes 35 p r i m a r y members from 18 basic and clinical departments within Duke University School of Medicine and the School of Engineering and 28 secondary members. Total funding (Direct + Indirect) for program members was $23.5M in 2013, of which $18M came from peer-reviewed sources. A cancer-focus was illustrated by $3.6M from the NCI, the American Cancer Society, or cancer-related Department of Defense programs. From 2009-2013, program members published 640 papers in peer- reviewed journals cited in PubMed. Of these publications, 4.6% were the result of intra-programmatic collaborations, 18% due to inter-programmatic collaborations, and 1.8% both. Note: Although it shares the same name as a program in existence at the time of the previous competitive renewal, CGG is essentially a new program started in 2012.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-44
Application #
9404312
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
44
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
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