The High Resolution NMR Shared Resource provides access to and technical support for over $6M worth of state-of-the-art instrumentation essential for modern magnetic resonance spectroscopy, and links to the NMR Facility at the North Carolina Research Campus in Kannapolis, NC, which has the only 950MHz Bruker instrument in the United States. The Shared Resource has gained a worldwide reputation for being active in the design and implementation of new methodologies in biological NMR and stable isotope labeling techniques, which are routinely brought to bear to advance DCI members' research. The Resource's expert staff train and assist users in both the fundamentals and the most modern and advanced applications of powerful NMR technologies. The group supports the research instrumentation needs of a variety of DCI areas and programs. Support for this resource comes from a combination of institutional funding, Cancer Center Support Grant funding, and user fees. A combination of institutional and external funding are used to support equipment purchases and upgrades in order to ensure availability of the highest performing NMR instrumentation to all DCI members. Over the past year, of the 29 active user groups of the NMR Shared Resource, 16 (55%) are members of the DCI. Of these 16, 14 have active peer reviewed funding. Our DCI users represent five of the nine DCI programs: Developmental Therapeutics, Neuro-Oncology, Cancer Genetics and Genomics, Cancer Control and Population Sciences, and Hematologic Malignancies and Cellular Therapies. The long-term objectives of the NMR Shared Resource are: (1) to continue efforts both to maintain state-of- the-art equipment and to enhance the resource to meet DCI members' needs; (2) to continue to monitor advances in NMR approaches aimed at characterizing biomolecular systems and to implement useful new techniques; (3) to prepare and submit internal and external proposals as appropriate to fund new equipment acquisitions and to incorporate advanced technology in order to support user needs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-45
Application #
9620032
Study Section
Subcommittee I - Career Development (NCI)
Project Start
Project End
Budget Start
2019-01-01
Budget End
2019-12-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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