Cancer Control and Population Sciences (CCPS) has been re-organized into three research focus areas: 1) Epidemiology, Etiology and Population Genomics Research; 2) Behavioral Research; and 3) Cancer Heath Services, Outcomes, Implementation Sciences, Comparative Effectiveness and Evidence-base policy (CHOICE). Major crosscutting themes, include cancer disparities and cancer health interventions. The overarching scientific goals of CCPS program are to 1) identify environmental, biological, psychosocial, genetic and epigenetic factors that affect cancer risk; 2) develop, implement, evaluate, and disseminate behavioral, communications, psychosocial, and clinical interventions focused on cancer prevention and community health and improving health care and quality of life for cancer survivors and those receiving palliative care; and 3) apply and advance cancer research across the full cancer research continuum (cells to society, prevention to survivorship) to impact the broader contexts of health systems and societal health through quality, economic, and policy studies. Particular strengths of CCPS within the focus areas are investigations in the molecular epidemiology of ovarian, brain, cervix, lung, and head and neck cancers; epigenetics of risk associated with prenatal exposures; tobacco cessation; community and practioner-patient communications; exercise-oncology; obesity; geriatric oncology; mobile health technology (mhealth); big-data platforms for integrating tumor registries with genomics; outcomes and economics; efficacy and economics of precision medicine; economics of end-of-life care; and patient-reported outcomes. CCPS currently comprises 59 primary and 9 secondary members across 13 departments, divisions, schools, and institutes. Despite flat NIH budgets, grant funding remains stable since our last submission, from $22 million in peer reviewed funding in 2009 to $23 million in 2013 (70% of the total direct + indirect funding of $32,561,901). Of the total peer reviewed funds, $7,816,844 (34%) is from NCI. During the recent five-year period, we have published over 1700 peer-reviewed papers; 220 papers (13%) demonstrate intra-programmatic collaborations, 310 papers (18%) demonstrate inter- programmatic collaborations and 91 (5%) demonstrated both inter- and intra-programmatic collaborations. Thus, more than a third of the publications represent inter- and/or intra-programmatic collaborations

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-45
Application #
9620054
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-01-01
Budget End
2019-12-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Dai, Ziwei; Mentch, Samantha J; Gao, Xia et al. (2018) Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nat Commun 9:1955
Powell Gray, Bethany; Kelly, Linsley; Ahrens, Douglas P et al. (2018) Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A 115:4761-4766
Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
Hudson, Kathryn E; Rizzieri, David; Thomas, Samantha M et al. (2018) Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study. Br J Haematol :
Fayanju, Oluwadamilola M; Park, Ko Un; Lucci, Anthony (2018) Molecular Genomic Testing for Breast Cancer: Utility for Surgeons. Ann Surg Oncol 25:512-519
Porter, Laura S; Fish, Laura; Steinhauser, Karen (2018) Themes Addressed by Couples With Advanced Cancer During a Communication Skills Training Intervention. J Pain Symptom Manage 56:252-258
Káradóttir, Ragnhildur T; Kuo, Chay T (2018) Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis. Annu Rev Neurosci 41:139-161
Han, Peng; Liu, Hongliang; Shi, Qiong et al. (2018) Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. Mol Carcinog 57:784-793
Xu, Yinghui; Wang, Yanru; Liu, Hongliang et al. (2018) Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival. Mol Carcinog 57:22-31
Abdi, Khadar; Kuo, Chay T (2018) Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling. Genes Dev 32:740-741

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