? OPTICAL MOLECULAR IMAGING AND ANALYSIS SHARED RESOURCE The Optical Molecular Imaging and Analysis (OMIA) shared resource provides in vivo optical imaging and spectroscopy ranging from whole animal fluorescence and bioluminescence to functional intravital microscopy. OMIA services can be broken down broadly according to the following categories: 1) optical imaging, 2) window chamber surgery training and support, 3) user training in techniques, and 4) scientific guidance on experimental design, data analysis and interpretation. Within optical imaging, two primary technological approaches are in vivo whole animal bioluminescence and fluorescence imaging. These are achieved using a set of commercial imaging devices, namely the IVIS Lumina and Kinetic, as well as FMT2500LX fluorescence tomography system (all from PerkinElmer). A third major technological approach within optical imaging is intravital microscopy. This approach is facilitated through resources developed over many years in the laboratories of the shared resource co-directors. The available resources include a surgical facility and the supplies needed for performing surgeries, as well as microscopes suitable for intravital functional imaging. Together, these three optical imaging capabilities, plus the other expertise, training, and services of OMIA, provide a unique resource for DCI members to study cancer therapeutics and tumor biology. This is a vital shared resource that, in 2018, provided services to 38 investigators, 71% of whom were DCI members, accounting for 74% of total usage, from all 8 DCI Research Programs. DCI members benefit in particular due to the availability of cost offsets that are proportional to the DCI contribution (typically 10-30% based on the service), as well as a wide range of cancer models, which account for the majority of the utilization of these services. The impact of this facility on DCI members is best highlighted by the fact that this shared resource contributed to 83 publications over the project period, 15 of which were in high impact journals (Impact Factor >9), demonstrating the value of services offered by the resource.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Duke University
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Wen, Juyi; Liu, Hongliang; Wang, Lili et al. (2018) Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy. J Thorac Oncol 13:660-675
Li, Bo; Wang, Yanru; Xu, Yinghui et al. (2018) Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer 142:2303-2312
Gearhart-Serna, Larisa M; Jayasundara, Nishad; Tacam Jr, Moises et al. (2018) Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations. J Environ Public Health 2018:5610462
Bakthavatsalam, Subha; Sleeper, Mark L; Dharani, Azim et al. (2018) Leveraging ?-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. Angew Chem Int Ed Engl 57:12780-12784
Dai, Ziwei; Mentch, Samantha J; Gao, Xia et al. (2018) Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nat Commun 9:1955
Powell Gray, Bethany; Kelly, Linsley; Ahrens, Douglas P et al. (2018) Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A 115:4761-4766
Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
Hudson, Kathryn E; Rizzieri, David; Thomas, Samantha M et al. (2018) Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study. Br J Haematol :
Fayanju, Oluwadamilola M; Park, Ko Un; Lucci, Anthony (2018) Molecular Genomic Testing for Breast Cancer: Utility for Surgeons. Ann Surg Oncol 25:512-519
Porter, Laura S; Fish, Laura; Steinhauser, Karen (2018) Themes Addressed by Couples With Advanced Cancer During a Communication Skills Training Intervention. J Pain Symptom Manage 56:252-258

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