? COMMUNITY OUTREACH AND ENGAGEMENT Since Duke Cancer Institute?s (DCI) inception in 2011, significant effort has gone into enhancing DCI Community Outreach and Engagement (COE) and addressing cancer health disparities. DCI uses patient data analytics to define its Catchment Area (CA) to the 85th percentile of its patient base, focused primarily on central North Carolina. DCI?s CA cancer burden was defined using a 3-pronged approach: 1) DCI senior leaders served with the State of North Carolina Advisory Committee on Cancer Coordination and Control (NC-ACCCC), the NC Cancer Prevention and Control Branch, and the NC Cancer Registry, to help conduct a county by county analysis of all cancers with a focus on cancers for which NC incidence and mortality rates either exceed the national averages, exhibit significant disparities, and/or are preventable; 2) DCI created a 20-member Community Advisory Board representing its local diversity and embarked on an extensive three-year community needs assessment campaign; and 3) DCI was one of the fifteen awardees in the first round NCI P30 supplements (2017) to assess the cancer risks and needs of its catchment area. DCI focuses significant effort on Community Outreach and Engagement (COE) including the 2012 launch of the DCI Office of Health Equity (OHE). Through these coordinated efforts DCI has identified prostate, lung, high-risk breast cancer, and GI cancers including colorectal and stomach, which are either major CA cancer burdens and/or disproportionately affect minority populations, as ?priority? target cancers in the next grant period. Tobacco, obesity and infectious agents were identified as major risk factors and cancer disparities identified as a major crosscutting challenge. This analysis guides our community engagement, community-based interventions, cancer care services, cancer health policy advocacy and research. DCI members conduct ground-breaking, multi-level research on these cancers and risk factors including research directed at understanding the social, structural and biological drivers of cancer disparities, as well as developing and implementing interventions. DCI COE is overseen by DCI?s Deputy Director, Steven Patierno, a nationally recognized expert in cancer disparities research and intervention. He works closely with Nadine Barrett, DCI Associate Director for COE, who also holds a joint DCI-CTSA sponsored position of Director of ?Alliances for Community Engagement and Stakeholder Strategy? (ACESS).
The Specific Aims for the next five years of DCI COE are: 1) to monitor the cancer-relevant needs of our Catchment Area to inform research relevant to our catchment area?s needs; 2) to perform research relevant to our catchment area?s needs and enhance the impact of our Cancer Center?s research to our Catchment Area; 3) to engage our Catchment Area communities in evidence-based strategies for cancer prevention, screening, treatment and outcomes research, with particular emphasis on underserved populations; 4) to extend DCI?s reach within and beyond our catchment area, through affiliates and other networks that bring DCI?s expertise to bear on wider populations, rural populations, and global cancer research.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
United States
Zip Code
Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
Hudson, Kathryn E; Rizzieri, David; Thomas, Samantha M et al. (2018) Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study. Br J Haematol :
Fayanju, Oluwadamilola M; Park, Ko Un; Lucci, Anthony (2018) Molecular Genomic Testing for Breast Cancer: Utility for Surgeons. Ann Surg Oncol 25:512-519
Porter, Laura S; Fish, Laura; Steinhauser, Karen (2018) Themes Addressed by Couples With Advanced Cancer During a Communication Skills Training Intervention. J Pain Symptom Manage 56:252-258
Káradóttir, Ragnhildur T; Kuo, Chay T (2018) Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis. Annu Rev Neurosci 41:139-161
Han, Peng; Liu, Hongliang; Shi, Qiong et al. (2018) Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. Mol Carcinog 57:784-793
Xu, Yinghui; Wang, Yanru; Liu, Hongliang et al. (2018) Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival. Mol Carcinog 57:22-31
Abdi, Khadar; Kuo, Chay T (2018) Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling. Genes Dev 32:740-741
Lu, Min; Sanderson, Sydney M; Zessin, Amelia et al. (2018) Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer. Cancer Metab 6:14
Qian, Danwen; Liu, Hongliang; Wang, Xiaomeng et al. (2018) Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival. Int J Cancer :

Showing the most recent 10 out of 513 publications