Abstract

The UWCCC Analytical Instrumentation Laboratory (AIL) provides a resource for bioanalytical chemistry and pharmacology studies to all UWCCC investigators. These services are important to many programs of the UWCCC, including those involved in clinical trials of new drugs and chemopreventative agents; studies of biochemical markers of drug effect and toxicity; and studies of mechanism of drug action and metabolism. In the last decade, pharmacokinetic/pharmacodynamic (PK/PD) studies have become an integral component of early clinical trials. The facility has the capability of setting up and executing a wide variety of assays as they are needed for new studies and can also offer many of the analytic assays of an ongoing basis as drugs move from early Phase I into Phase II and combination trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA014520-27S2
Application #
6217222
Study Section
Project Start
1999-04-16
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
27
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Cummings, Nicole E; Williams, Elizabeth M; Kasza, Ildiko et al. (2018) Restoration of metabolic health by decreased consumption of branched-chain amino acids. J Physiol 596:623-645
McDaniel, Nellie K; Cummings, Christopher T; Iida, Mari et al. (2018) MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents. Mol Cancer Ther 17:2297-2308
Lee, Cindy S; Sickles, Edward A; Burnside, Elizabeth S (2018) Data-Driven Mammography Screening Practices-Reply. JAMA Oncol 4:588-589
Djavadian, Reza; Hayes, Mitchell; Johannsen, Eric (2018) CAGE-seq analysis of Epstein-Barr virus lytic gene transcription: 3 kinetic classes from 2 mechanisms. PLoS Pathog 14:e1007114
Engle, Jeff A; Traynor, Anne M; Campbell, Toby C et al. (2018) Assessment of adherence and relative dose intensity with oral chemotherapy in oncology clinical trials at an academic medical center. J Oncol Pharm Pract 24:348-353
Tanratana, Pansakorn; Ellery, Paul; Westmark, Pamela et al. (2018) Elevated Plasma Factor IXa Activity in Premenopausal Women on Hormonal Contraception. Arterioscler Thromb Vasc Biol 38:266-274
Mora-Pinzon, Maria C; Chrischilles, Elizabeth A; Greenlee, Robert T et al. (2018) Variation in coordination of care reported by breast cancer patients according to health literacy. Support Care Cancer :
Tucholka, J L; Jacobson, N; Steffens, N M et al. (2018) Breast cancer survivor's perspectives on the role different providers play in follow-up care. Support Care Cancer 26:2015-2022
Mukaddim, Rashid Al; Rodgers, Allison; Hacker, Timothy A et al. (2018) Real-Time in Vivo Photoacoustic Imaging in the Assessment of Myocardial Dynamics in Murine Model of Myocardial Ischemia. Ultrasound Med Biol 44:2155-2164
Eslani, Medi; Putra, Ilham; Shen, Xiang et al. (2018) Cornea-Derived Mesenchymal Stromal Cells Therapeutically Modulate Macrophage Immunophenotype and Angiogenic Function. Stem Cells 36:775-784

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