The UWCCC Small Animal Imaging Facility provides innovative, state-of-the-art, affordable, noninvasive, high-resolution in-vivo and ex-vivo imaging support to UWCCC members who utilize small animal models in their research. The facility director and manager provide consultation with investigators about methodologies most suited to answer their biological questions. Investigators are able to select various levels of support ranging from image acquisition alone, to acquisition and reconstruction, to image interpretation and finally to media presentation. Because of their radiochemistry expertise, they also radiolabel small molecules or proteins for investigators prior to imaging. Anatomic MicroCT Scanning. A MicroCAT-2 from Siemens/CTI is equipped with a large field-of-view detector, thus allowing high resolution scanning (18 micron)'of rats up to 300 grams. The system is equipped with a rodent isoflurane gas anesthesia system and physiologic monitoring system which allows image gating, Functional MicroPET Scanning. Functional microPET imaging is also available. Because both scanners are from the same manufacturer, the scanning beds are completely interchangeable which allows scanning with both modalities without moving the animal, thus allowing fairly accurate fusion of the two data sets. We are scheduled to acquire the first commercial microCT/microPET hybrid scanner from Siemens/CTI in June of 2006. This world's first hybrid scanner coupled with our own proprietary cell-selective imaging and contrast agents affords our investigators unique tumor detection and evaluation technologies which can only be provided here.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014520-36
Application #
7809603
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
36
Fiscal Year
2009
Total Cost
$144,563
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Wei, Weijun; Ni, Dalong; Ehlerding, Emily B et al. (2018) PET Imaging of Receptor Tyrosine Kinases in Cancer. Mol Cancer Ther 17:1625-1636
Saghiri, Mohammad Ali; Asatourian, Armen; Sorenson, Christine M et al. (2018) Mice dental pulp and periodontal ligament endothelial cells exhibit different proangiogenic properties. Tissue Cell 50:31-36
Shi, Sixiang; Chen, Feng; Goel, Shreya et al. (2018) In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem. Nanomicro Lett 10:65
Ni, Dalong; Jiang, Dawei; Im, Hyung-Jun et al. (2018) Radiolabeled polyoxometalate clusters: Kidney dysfunction evaluation and tumor diagnosis by positron emission tomography imaging. Biomaterials 171:144-152
Li, Jun; Kang, Lei; Yu, Yanhao et al. (2018) Study of Long-Term Biocompatibility and Bio-Safety of Implantable Nanogenerators. Nano Energy 51:728-735
Ni, Dalong; Ehlerding, Emily B; Cai, Weibo (2018) Multimodality Imaging Agents with PET as the Fundamental Pillar. Angew Chem Int Ed Engl :
Niemeier, Ryan C; Etoz, Sevde; Gil, Daniel A et al. (2018) Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones. Biomed Opt Express 9:1648-1663
Katsumura, Koichi R; Mehta, Charu; Hewitt, Kyle J et al. (2018) Human leukemia mutations corrupt but do not abrogate GATA-2 function. Proc Natl Acad Sci U S A 115:E10109-E10118
Coriano, Carlos G; Liu, Fabao; Sievers, Chelsie K et al. (2018) A Computational-Based Approach to Identify Estrogen Receptor ?/? Heterodimer Selective Ligands. Mol Pharmacol 93:197-207
Kong, Guangyao; You, Xiaona; Wen, Zhi et al. (2018) Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia :

Showing the most recent 10 out of 1528 publications