The long-term goal of UWCCC Community Outreach and Engagement activities is to decrease cancer incidence and mortality among populations within our catchment area and beyond, including our minority and underserved populations. We will achieve this goal through partnerships with other health delivery systems and state and community agencies for dissemination of evidence-based findings.
Our specific aims are: (1) to understand our catchment area population through improved data collection and analysis, with a special emphasis on identifying disparities, (2) to engage our catchment area and state in clinical trials that are relevant to and appropriate for our populations, including underserved populations, and (3) to work with and serve our community organizations, affiliated health systems, and regional networks in the dissemination and implementation of evidence-based interventions and health policy recommendations, particularly for underserved populations. To accomplish these aims, the UWCCC engages researchers to build the evidence base for interventions to benefit our catchment area and beyond, as well as integrate what we learn from our catchment area into future research. Our UWCCC engagement activities and scientific programs have focused on areas of significant cancer burden within our 36- county catchment, including lung, breast, colorectal, and prostate cancer. Focus areas include lung and breast cancer among African Americans, cervical cancer among Hispanics, lung and colorectal cancer among American Indians, and delays in diagnosis among our rural residents. Colonoscopy screening rates are low and smoking rates are high among low income residents, while alcohol consumption is high. Through leveraging our extensive networks for research and outreach, we will engage our catchment area residents in clinical trials and the broad- based activities that have been shown to improve the health of, and in particular for, our disadvantaged populations. We specifically expand engagement of our catchment area participants in clinical trials facilitated through the National Clinical Trials Network, the Veterans Administration Hospitals and Clinics, the Precision Medicine Molecular Tumor Board, and the UW Center for Tobacco Research and Intervention. Disparities in clinical trial recruitment will be targeted by assessing and addressing barriers to clinical trials participation, improving recruitment materials, and developing targeted and culturally appropriate outreach. Our broad-based outreach activities include dissemination and implementation of evidence-based interventions and health policy recommendations for tobacco cessation, HPV vaccine uptake, colorectal cancer screening, and alcohol use. We will also continue to expand our Cancer Clear and Simple curriculum developed specifically for rural areas. Overall, we expect that these activities will continue to have a substantial positive impact on reducing the burden of cancer within our catchment area.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA014520-44
Application #
9490028
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-05-30
Budget End
2019-03-31
Support Year
44
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Wargowski, Ellen; Johnson, Laura E; Eickhoff, Jens C et al. (2018) Prime-boost vaccination targeting prostatic acid phosphatase (PAP) in patients with metastatic castration-resistant prostate cancer (mCRPC) using Sipuleucel-T and a DNA vaccine. J Immunother Cancer 6:21
Bednarz, Bryan; Grudzinski, Joseph; Marsh, Ian et al. (2018) Murine-specific Internal Dosimetry for Preclinical Investigations of Imaging and Therapeutic Agents. Health Phys 114:450-459
Romero-Masters, James C; Ohashi, Makoto; Djavadian, Reza et al. (2018) An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model. PLoS Pathog 14:e1007221
Xu, Cheng; Chen, Feng; Valdovinos, Hector F et al. (2018) Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy. Biomaterials 165:56-65
Lu, Zhanping; Hong, Courtney C; Kong, Guangyao et al. (2018) Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep 22:1545-1559
Shea, Michael P; O'Leary, Kathleen A; Fakhraldeen, Saja A et al. (2018) Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ER?+ Mammary Carcinomas. Cancer Res 78:1672-1684
Schrager, Sarina; Burnside, Elizabeth (2018) Breast Cancer Screening in Primary Care: A Call for Development and Validation of Patient-Oriented Shared Decision-Making Tools. J Womens Health (Larchmt) :
van den Broek, Jeroen J; van Ravesteyn, Nicolien T; Mandelblatt, Jeanne S et al. (2018) Comparing CISNET Breast Cancer Incidence and Mortality Predictions to Observed Clinical Trial Results of Mammography Screening from Ages 40 to 49. Med Decis Making 38:140S-150S
Liu, Bai; Jones, Monica; Kong, Lin et al. (2018) Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models. Cytokine 107:105-112
Yu, Deyang; Yang, Shany E; Miller, Blake R et al. (2018) Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. FASEB J 32:3471-3482

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