UWCCC Tumor Microenvironment (TM) Program Summary Co-Leaders: Patricia Keely and David Beebe PROJECT SUMMARY/ABSTRACT Tumors are complex systems composed of tumor cells, stromal cells, soluble factors, and the extracellular matrix (ECM); together, these components constitute the tumor microenvironment. While cancer research has focused historically on studying and treating the tumor cell, it is now clear that the other components of the tumor microenvironment are active participants in tumor progression. For example, growth factors secreted by tumor cells attract immune cells into the tumor microenvironment; these immune cells in turn provide cytokines and other factors that stimulate stromal cell deposition and remodeling of ECM, which feedback to influence tumor cell behavior. Although the tumor microenvironment is undoubtedly important in the progression of several types of cancer, therapeutic approaches targeted against the microenvironment remain rare, in part, because knowledge in this area is insufficient. Therefore, it is the mission of the Tumor Microenvironment (TM) Program to identify microenvironmental changes that occur during tumorigenesis and analyze how the interactions between the tumor cell and microenvironmental components affect tumor formation, growth, progression, and ultimately metastasis. To accomplish these goals, the TM program fosters collaborations between its 32 members from 17 departments - basic scientists, clinicians, and bioengineers who specialize in the development of systems that mimic the in vivo environment and computational modeling of systems-level behaviors. TM program research is organized into three thematic areas: 1) Extracellular Matrix, 2) Engineering Approaches, and 3) Immune Interactions. Program members were supported by $3.0 million direct costs in NCI-funding and $10.6 million direct costs in total peer-reviewed cancer-related support, and were highly productive with 494 publications during the course of the last grant. Of these publications, 13% were intra- programmatic collaborations and 24% were inter-programmatic collaborations. In the year 2016 alone, nearly 50% of publications were collaborative with other institutions. Through these research efforts, members of the TM program are identifying new biomarkers and therapeutic approaches.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of Wisconsin Madison
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Chang, Julie E; Carmichael, Lakeesha L; Kim, KyungMann et al. (2018) VcR-CVAD Induction Chemotherapy Followed by Maintenance Rituximab Produces Durable Remissions in Mantle Cell Lymphoma: A Wisconsin Oncology Network Study. Clin Lymphoma Myeloma Leuk 18:e61-e67
Guerrero, Natalie; Small, Alissa L; Schwei, Rebecca J et al. (2018) Informing physician strategies to overcome language barriers in encounters with pediatric patients. Patient Educ Couns 101:653-658
Chapelin, Fanny; Capitini, Christian M; Ahrens, Eric T (2018) Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer. J Immunother Cancer 6:105
Ni, Dalong; Ferreira, Carolina A; Barnhart, Todd E et al. (2018) Magnetic Targeting of Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy. J Am Chem Soc 140:14971-14979
Wang, Dongdong; Shi, Ruohong; Zhou, Jiajia et al. (2018) Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy. iScience 9:14-26
Pearson, Hannah E; Iida, Mari; Orbuch, Rachel A et al. (2018) Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol. Mol Cancer Ther 17:204-214
Mora-Pinzon, Maria C; Trentham-Dietz, Amy; Gangnon, Ronald E et al. (2018) Urinary Magnesium and Other Elements in Relation to Mammographic Breast Density, a Measure of Breast Cancer Risk. Nutr Cancer 70:441-446
DuBenske, Lori L; Schrager, Sarina B; Hitchcock, Mary E et al. (2018) Key Elements of Mammography Shared Decision-Making: a Scoping Review of the Literature. J Gen Intern Med 33:1805-1814
Chen, Feng; Goel, Shreya; Shi, Sixiang et al. (2018) General synthesis of silica-based yolk/shell hybrid nanomaterials and in vivo tumor vasculature targeting. Nano Res 11:4890-4904
Erbe, Amy K; Wang, Wei; Carmichael, Lakeesha et al. (2018) Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group. Clin Cancer Res 24:189-196

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