This is a multifaceted, interdisciplinary program whose objectives are the elucidation of the mechanisms by which three human herpes viruses, i.e., herpes simplex virus 1, herpes simplex virus 2, and Epstein-Barr virus, replicate, maintain themselves in latent infection, and transform cells. The facility also serves as the center for teaching predoctoral and postdoctoral trainees supported by a training grant from the National Cancer Institute and by individual fellowship grants from such sources as National Institutes of Health, the American Cancer Society, Damon Runyon-Walter Winchell Foundation, and the Leukemia Society. The shared facility is the Majorie B. Kovler Viral Oncology Laboratories, which has 35,000 gross sq. ft. and 18,000 net sq. ft. It was designed as a containment facility for use with hazardous virus and was built with the aid of grant from the National Cancer Institute. The facility houses the research programs of Drs. Frenkel, Kieff, Roizman and Spear. These programs currently contain approximately 16 postdoctoral trainees and fellows, 23 predoctoral students, and 20 technical personnel. The facility is fully equipped for research work in molecular virology and oncology. It contains an electron microscope with appropriate accessories, a fully equipped dark room with film developing and printing equipment, high- and low-speed centrifuges, scintillation counters, laminar flow rooms and hood, warm rooms and a cold room, an HP9000 computer with graphics and printing peripherals and terminals throughout the building, glassware washing facilities, a conference room, and miscellaneous other equipment that is shared among the various investigators.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-18
Application #
3805527
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Trujillo, Jonathan A; Sweis, Randy F; Bao, Riyue et al. (2018) T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection. Cancer Immunol Res 6:990-1000
Zeng, Zongyue; Huang, Bo; Huang, Shifeng et al. (2018) The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs. Genes Dis 5:62-74
Lee, Ji-Hye; Park, Beom Seok; Han, Kang R et al. (2018) Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol 9:1466
Cheng, Jason X; Chen, Li; Li, Yuan et al. (2018) RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat Commun 9:1163
Johnson, Marianna B; Hoffmann, Joscelyn N; You, Hannah M et al. (2018) Psychosocial Stress Exposure Disrupts Mammary Gland Development. J Mammary Gland Biol Neoplasia 23:59-73
Sweis, Randy F; Zha, Yuanyuan; Pass, Lomax et al. (2018) Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer. J Immunother Cancer 6:24
Kathayat, Rahul S; Cao, Yang; Elvira, Pablo D et al. (2018) Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun 9:334
Liu, Jun; Eckert, Mark A; Harada, Bryan T et al. (2018) m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol 20:1074-1083
Bhanvadia, Raj R; VanOpstall, Calvin; Brechka, Hannah et al. (2018) MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease. Clin Cancer Res 24:3668-3680
Wood, Kevin; Byron, Elizabeth; Janisch, Linda et al. (2018) Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms. Am J Clin Oncol 41:963-966

Showing the most recent 10 out of 668 publications