The overall goal of the UCCRC program in Immunology and Cancer is to dissect the multiple closely interrelated factors that determine immune responses to conventional and tumor antigens. This program is closely related to the Committee on Immunology which has been highly successful in developing interactive research and educational efforts to enhance the scientific endeavors of the UCCRC and the University. One example of the interactive nature of this program is the ongoing USPHS-NCI Program Project: """"""""Immunity and Cancer"""""""" H. Schreiber, Program Director. The overall goals of the UCCRC Program in Immunology and Cancer are: (1) to enhance the scientific interactions among the various immunology researchers interested in cancer; (2) to bring together individuals interested in the most basic elements of the immune response to coordinate efforts towards a better understanding of tumor immunology; (3) to develop organized educational programs for predoctoral and postdoctoral students in order to foster increased interest in cancer research and (4) to manipulate the immune system in the treatment of cancer. Ultimately, these activities will lead to developing preclinical models to test novel immunotherapies for cancer and clinical studies through collaborative efforts with the Developmental Therapeutics Program of the UCCRC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-20
Application #
3771083
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Meisel, Marlies; Hinterleitner, Reinhard; Pacis, Alain et al. (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557:580-584
Ni, Kaiyuan; Lan, Guangxu; Chan, Christina et al. (2018) Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun 9:2351
Wei, Jiangbo; Liu, Fange; Lu, Zhike et al. (2018) Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol Cell 71:973-985.e5
Webber, Jemma L; Zhang, Jie; Massey, Alex et al. (2018) Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Development 145:
Szmulewitz, Russell Z; Peer, Cody J; Ibraheem, Abiola et al. (2018) Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer. J Clin Oncol 36:1389-1395
Boisclair Lachance, Jean-François; Webber, Jemma L; Hong, Lu et al. (2018) Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev 32:389-401
Kudron, Michelle M; Victorsen, Alec; Gevirtzman, Louis et al. (2018) The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. Genetics 208:937-949
Maron, Steven B; Alpert, Lindsay; Kwak, Heewon A et al. (2018) Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for EGFR-Amplified Gastroesophageal Adenocarcinoma. Cancer Discov 8:696-713
Kane, Melissa; Deiss, Felicity; Chervonsky, Alexander et al. (2018) A Single Locus Controls Interferon Gamma-Independent Antiretroviral Neutralizing Antibody Responses. J Virol 92:
Zeineddine, Hussein A; Girard, Romuald; Saadat, Laleh et al. (2018) Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest :

Showing the most recent 10 out of 668 publications