Over the past five years. Developmental Funds have been used to support Pilot Projects, recruitment of new Investigators, and development of new Core Facilities to further UCCCC strategic goals, including expansion of population and translational research, immunotherapy, and interdisciplinary and interprogrammatic collaborations. From 2008-2012, a CCSG Investment of $1,519,611 has yielded a remarkable return of $33,870,022 In peer-reviewed support, as well as publications and programmatic development. Support for 10 new investigators has contributed to enhancements in the Molecular Mechanisms of Cancer, Hematopoiesis and Hematological Malignancies, Pharmacogenomics and Experimental Therapeutics and Cancer Prevention and Control Programs. With one exception, all of these faculty have remained at the institution and are active members of the UCCCC. Examples of significant recruitments include: Tina Shih, PhD, a cancer economist who is leading the development of cancer economics in the CPC Program;Jianjun Chen, PhD, whose research in genetic and epigenetic alterations in leukemia and lymphoma strengthens the HHM Program, and Peter O'Donnell, MD, who is applying his expertise in pharmacogenomics and its application to lead the 1200 Patient Trial. Four new developing Core Facilities were supported with CCSG developmental funds: Epidemiology and Research Recruitment Core (ERRC), Human Imaging Research Office (HIRO), Metabolomics, and the Biofluids Unit, the latter now a full component of the Pharmacology Core Facility. In addition, unique bioinformatics services (next-generation sequencing informatics) were added to the Biostatistics Core Facility, and have now been integrated into the institutional Bioinformatics Core (a developing UCCCC core). The developing cores continue to grow and have significantly contributed to interdisciplinary collaborations and translational research. Over the next grant period, we are requesting $360,000/year for: 1) recruitment of new investigators ($120K);2) Program development/Program Pilot Projects ($140K);and 3) development of new Core Facilities ($100K). These funds will be used to further the three components of our Strategic Plan: 1) the Personalized Cancer Care Consortium (PCCC);2) the Center for Cancer Prevention and Population Medicine;and 3) the Program in Cancer Survivorship, Cancer Economics, and Outcomes. We will support the ERRC, HIRO, Bioinformatics, and Metabolomics developing cores in the initial years of the next CCSG cycle. It is anticipated that as the needs for other new technologies are identified, CCSG developmental funds will be applied to their development.

Public Health Relevance

Developmental Funds represents a critical component of the CCSG used to further strategic initiatives. These funds are often combined with, and can be used to leverage, institutional and philanthropic support. They provide an Important mechanism for Program Leaders in the development of targeted research areas, enable UCCCC leadership to respond to the identification of new Core Facility needs, as well as influence institutional initiatives In recruitment and Facility development.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-39
Application #
8744847
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
39
Fiscal Year
2014
Total Cost
$251,694
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Zeineddine, Hussein A; Girard, Romuald; Saadat, Laleh et al. (2018) Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest :
Kane, Melissa; Deiss, Felicity; Chervonsky, Alexander et al. (2018) A Single Locus Controls Interferon Gamma-Independent Antiretroviral Neutralizing Antibody Responses. J Virol 92:
Xiao, Annie; Crosby, Jennie; Malin, Martha et al. (2018) Single-institution report of setup margins of voluntary deep-inspiration breath-hold (DIBH) whole breast radiotherapy implemented with real-time surface imaging. J Appl Clin Med Phys 19:205-213
Gamazon, Eric R; Trendowski, Matthew R; Wen, Yujia et al. (2018) Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma. Sci Rep 8:733
Girard, Romuald; Zeineddine, Hussein A; Koskimäki, Janne et al. (2018) Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth. Circ Res 122:1716-1721
Day, Kasey J; Casler, Jason C; Glick, Benjamin S (2018) Budding Yeast Has a Minimal Endomembrane System. Dev Cell 44:56-72.e4
Pu, Jinyue; Kentala, Kaitlin; Dickinson, Bryan C (2018) Multidimensional Control of Cas9 by Evolved RNA Polymerase-Based Biosensors. ACS Chem Biol 13:431-437
Pectasides, Eirini; Stachler, Matthew D; Derks, Sarah et al. (2018) Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma. Cancer Discov 8:37-48
Liu, Hongtao; Zha, Yuanyuan; Choudhury, Noura et al. (2018) WT1 peptide vaccine in Montanide in contrast to poly ICLC, is able to induce WT1-specific immune response with TCR clonal enrichment in myeloid leukemia. Exp Hematol Oncol 7:1
Nageeb, Shaheen; Vu, Milkie; Malik, Sana et al. (2018) Adapting a religious health fatalism measure for use in Muslim populations. PLoS One 13:e0206898

Showing the most recent 10 out of 668 publications