The Cancer Prevention and Control (CPC) Program is engaged in defining, evaluating, and implementing novel interventions to reduce cancer incidence, minimize disease- and treatment-related symptoms, and enhance overall survivorship. CPC investigators apply state-of-the-science agents, assays, and study designs to advance the field in 2 prioritized areas: 1) Cancer Risk Reduction, including chemoprevention, tobacco control, and cancer early detection research; and 2) Symptom Control & Survivorship, integrating basic, clinical, and community-based studies to improve cancer care. This intentionally focused framework provides an efficient structure for innovative, collaborative investigation in both the cancer prevention and cancer control settings. CPC Risk Reduction research activities are concentrated on inhibiting preinvasive neoplasia, precluding (or lowering) tobacco exposure, and identifying asymptomatic tumors at the earliest possible stage. For Symptom Control and Survivorship, research activities are directed at eliminating or controlling untoward symptoms related to disease progression or treatment, and optimizing quality and quantity of life following a cancer diagnosis. To achieve its intended goals, the CPC Program has assembled an interdisciplinary team of 50 members from 20 departments across all 3 Mayo Clinic campuses. Total direct peer-reviewed funding is $4.1M (54% from the NCI), and total direct funding is $5.2M. Since 2013, the Program has generated 661 publications, 26% reflecting intraprogrammatic collaborations and 33% reflecting interprogrammatic collaborations. Notable contributions have been made with respect to each Program aim, as evidenced by the incorporation of study results into chemoprevention agent development planning, clinical practice standards, and public health policies. Dr. Loprinzi co-leads the CPC Program along with Dr. Limburg, who joined the leadership dyad in June 2017. Under this leadership pairing, the Program has reorganized its research activities to provide a strong foundation for accelerating impactful research and has also launched several new initiatives to increase opportunities for collaboration between the CPC Program and other key internal and external stakeholder groups. Major CPC Program activities anticipated for the next 5 years include further conduct of cutting-edge, team-based research related to the discovery, translation, and application of promising chemoprevention agents, cancer vaccines, tobacco cessation and nicotine avoidance strategies, early-detection biomarkers, multi-organ screening approaches (such as ?liquid biopsy?), imaging technologies, symptom management, and survivorship care. The Program makes extensive use of Shared Resources, in particular: Biospecimens Accessioning and Processing (BAP), Biostatistics (BSR), Genome Analysis (GEN), Pharmacy (PHM) and the MCCC Clinical Research Office (CRO).

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Dasari, Surendra; Newsom, Sean A; Ehrlicher, Sarah E et al. (2018) Remodeling of skeletal muscle mitochondrial proteome with high-fat diet involves greater changes to ?-oxidation than electron transfer proteins in mice. Am J Physiol Endocrinol Metab 315:E425-E434
Nowsheen, Somaira; Aziz, Khaled; Aziz, Asef et al. (2018) L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nat Cell Biol 20:455-464
Razidlo, Gina L; Burton, Kevin M; McNiven, Mark A (2018) Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42. J Biol Chem 293:11143-11153
Wu, Dongyan; Yang, Haitao; Winham, Stacey J et al. (2018) Mediation analysis of alcohol consumption, DNA methylation, and epithelial ovarian cancer. J Hum Genet 63:339-348
Leon-Ferre, Roberto A; Polley, Mei-Yin; Liu, Heshan et al. (2018) Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer. Breast Cancer Res Treat 167:89-99
Jahanseir, Khadijeh; Xing, Deyin; Greipp, Patricia T et al. (2018) PDGFB Rearrangements in Dermatofibrosarcoma Protuberans of the Vulva: A Study of 11 Cases Including Myxoid and Fibrosarcomatous Variants. Int J Gynecol Pathol 37:537-546
Painter, Jodie N; O'Mara, Tracy A; Morris, Andrew P et al. (2018) Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. Cancer Med 7:1978-1987
Yu, Jia; Qin, Bo; Moyer, Ann M et al. (2018) DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine. J Clin Invest 128:2376-2388
Sugihara, Takaaki; Werneburg, Nathan W; Hernandez, Matthew C et al. (2018) YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity. Mol Cancer Res 16:1556-1567

Showing the most recent 10 out of 1129 publications