Abstract

During the past grant period, developmental funds supported the recruitment of 20 productive Consortium faculty members in areas of strategic growth, including 12 clinical investigators working on solid-tumor cancer;44 pilot projects resulting in the acquisition of 27 grants and the publication of 34 papers;and the development of three shared resources in Imaging, High Throughput Genetics and Immune Monitoring. In this competing application, developmental funds are also requested for activities in these three areas as summarized below: 1. Faculty recruitment: CCSG funds are requested to support funding for five new recruits per year in areas of high strategic importance to the Consortium. The Consortium typically recruits 10 to 20 new members per year. 2. Pilot projects: CCSG funds are requested to fund nine to 11 pilot research projects of Consortium members each year. 3. Shared resources: Funding is requested for four shared resources of critical need to Consortium investigators - Bioinformatics;High Throughput Screening, Tissue Bank, and Tumor Models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA015704-35
Application #
7944653
Study Section
Subcommittee G - Education (NCI)
Project Start
2009-03-10
Project End
2013-12-31
Budget Start
2009-03-10
Budget End
2009-12-31
Support Year
35
Fiscal Year
2009
Total Cost
$2,400,533
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Cheng, Heather H (2018) The resounding effect of DNA repair deficiency in prostate cancer. Urol Oncol 36:385-388
Poudel, Kumud R; Roh-Johnson, Minna; Su, Allen et al. (2018) Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Dev Cell 45:738-752.e6
Holly, Mayumi K; Smith, Jason G (2018) Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells. J Virol :
Eaton, Keith D; Romine, Perrin E; Goodman, Gary E et al. (2018) Inflammatory Gene Polymorphisms in Lung Cancer Susceptibility. J Thorac Oncol 13:649-659
Bar, Merav; Flowers, Mary E D; Storer, Barry E et al. (2018) Reversal of Low Donor Chimerism after Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusion: A Prospective Phase II Multicenter Trial. Biol Blood Marrow Transplant 24:308-313
Gauthier, Jordan; Turtle, Cameron J (2018) Insights into cytokine release syndrome and neurotoxicity after CD19-specific CAR-T cell therapy. Curr Res Transl Med 66:50-52
Graves, Scott S; Parker, Maura H; Stone, Diane et al. (2018) Anti-Inducible Costimulator Monoclonal Antibody Treatment of Canine Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant 24:50-54
Amundsen, Susan K; Smith, Gerald R (2018) The RecB helicase-nuclease tether mediates Chi hotspot control of RecBCD enzyme. Nucleic Acids Res :
Méndez, Eduardo; Rodriguez, Cristina P; Kao, Michael C et al. (2018) A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 24:2740-2748
Buckley, Sarah A; Percival, Mary-Elizabeth; Othus, Megan et al. (2018) A comparison of patients with acute myeloid leukemia and high-risk myelodysplastic syndrome treated on versus off study. Leuk Lymphoma :1-7

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