Abstract

The Research Pathology Shared Resource (RPSR) provides state of the art, cost-effective, readily accessible services and instrumentation that allow for the microscopic analysis of tissue and cells. The resource includes two service-based laboratories, the Experimental Histopathology Laboratory (EHL) and the Specialized Pathology Laboratory (SPL). The EHL provides tissue harvesting at necropsy, expert consultation on fixation and processing specific for staining and subsequent immunohistochemistry, laser capture microdissection, and digital pathology slide scanning and/or unbiased expert interpretation. The SPL provides tissue microarray consultation, construction, imaging and interpretation, and expert pathology review for solid tumor specimens from large research studies. These services make it possible for individual investigators to apply methods that otherwise would not be available to them due either to the lack of expertise and/or lack of funds to introduce the expertise to their lab.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA015704-43
Application #
9406705
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
43
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Hay, Kevin A; Turtle, Cameron J (2018) CD19-specific chimeric antigen receptor-modified (CAR)-T cell therapy for the treatment of chronic lymphocytic leukemia in the ibrutinib era. Immunotherapy 10:251-254
Davis, Ryan J; Gönen, Mehmet; Margineantu, Daciana H et al. (2018) Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism. Proc Natl Acad Sci U S A 115:5462-5467
Sillah, Arthur; Watson, Nathaniel F; Schwartz, Stephen M et al. (2018) Sleep apnea and subsequent cancer incidence. Cancer Causes Control 29:987-994
He, Qianchuan; Liu, Yang; Sun, Wei (2018) Statistical analysis of non-coding RNA data. Cancer Lett 417:161-167
Ginos, Bigina N R; Navarro, Sandi L; Schwarz, Yvonne et al. (2018) Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding stud Metabolism 83:197-204
Sullivan, Kevin M; Kenerson, Heidi L; Pillarisetty, Venu G et al. (2018) Precision oncology in liver cancer. Ann Transl Med 6:285
Yeung, Cecilia C S; McElhone, Scott; Chen, Xue Yan et al. (2018) Impact of copy neutral loss of heterozygosity and total genome aberrations on survival in myelodysplastic syndrome. Mod Pathol 31:569-580
Leger, Kasey J; Baker, K Scott; Cushing-Haugen, Kara L et al. (2018) Lifestyle factors and subsequent ischemic heart disease risk after hematopoietic cell transplantation. Cancer 124:1507-1515
Ranola, John Michael O; Pearlman, Rachel; Hampel, Heather et al. (2018) Modified capture-recapture estimates of the number of families with Lynch syndrome in Central Ohio. Fam Cancer :
Dai, James Y; Liang, C Jason; LeBlanc, Michael et al. (2018) Case-only approach to identifying markers predicting treatment effects on the relative risk scale. Biometrics 74:753-763

Showing the most recent 10 out of 1267 publications